Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity (Q39978729)

16 September 2017

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity (English)

1 reference

16 September 2017

Lucía Chávez-Gutiérrez

1

1 reference

16 September 2017

Alexandra Tolia

2

1 reference

16 September 2017

Elke Maes

3

1 reference

16 September 2017

Tong Li

4

1 reference

16 September 2017

Philip C Wong

5

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16 September 2017

Bart de Strooper

6

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16 September 2017

language of work or name

English

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publication date

23 May 2008

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Journal of Biological Chemistry

16 September 2017

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16 September 2017

283

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16 September 2017

20096-20105

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16 September 2017

29

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Gamma-secretase: proteasome of the membrane?

16 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Activity of gamma-secretase on substrates other than APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

A cell biological perspective on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Genetics leads the way to the accomplices of presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Gamma-secretase complex assembly within the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

A glutamate residue contributes to the exopeptidase specificity in aminopeptidase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Study of asparagine 353 in aminopeptidase A: characterization of a novel motif (GXMEN) implicated in exopeptidase specificity of monozinc aminopeptidases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Leukotriene A4 hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Binding of inhibitory aromatic amino acids to Streptomyces griseus aminopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Recombinant adenovirus is an appropriate vector for endocytotic protein trafficking studies in cultured neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Arrayed adenoviral expression libraries for functional screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Exploring the extremes of sequence/structure space with ensemble fold recognition in the program Phyre

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Improvement of the GenTHREADER method for genomic fold recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

GenTHREADER: an efficient and reliable protein fold recognition method for genomic sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Nicastrin binds to membrane-tethered Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Crystal structure of the ectodomain of human transferrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

HFE modulates transferrin receptor 2 levels in hepatoma cells via interactions that differ from transferrin receptor 1-HFE interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

Mechanism for multiple ligand recognition by the human transferrin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M803040200

21 January 2018

Identifiers

DOI

10.1074/JBC.M803040200

1 reference

16 September 2017

1 reference