Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy (Q35065205)

6 August 2017

title

Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy (English)

1 reference

6 August 2017

Fabiana Renzi

1

1 reference

6 August 2017

Xulun Zhang

2

1 reference

6 August 2017

William J Rice

3

1 reference

6 August 2017

Celia Torres-Arancivia

4

1 reference

6 August 2017

Yacob Gomez-Llorente

5

1 reference

6 August 2017

Ruben Diaz

6

1 reference

6 August 2017

Kwangwook Ahn

7

1 reference

6 August 2017

Chunjiang Yu

8

1 reference

6 August 2017

Yue-Ming Li

9

1 reference

6 August 2017

Sangram S Sisodia

10

1 reference

6 August 2017

Iban Ubarretxena-Belandia

11

1 reference

6 August 2017

language of work or name

English

0 references

publication date

17 March 2011

1 reference

Journal of Biological Chemistry

6 August 2017

published in

1 reference

6 August 2017

volume

286

1 reference

6 August 2017

issue

24

1 reference

6 August 2017

page(s)

21440-21449

1 reference

Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers

6 August 2017

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8 July 2018

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8 July 2018

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Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

8 July 2018

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Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

8 July 2018

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A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

8 July 2018

1 reference

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

8 July 2018

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8 July 2018

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Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

8 July 2018

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Purification and characterization of the human gamma-secretase complex

8 July 2018

1 reference

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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

8 July 2018

1 reference

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Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

8 July 2018

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8 July 2018

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A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

8 July 2018

1 reference

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Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

8 July 2018

1 reference

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Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

8 July 2018

1 reference

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Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

8 July 2018

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Accurate determination of local defocus and specimen tilt in electron microscopy

8 July 2018

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

8 July 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

8 July 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

Gamma-secretase activity is associated with a conformational change of nicastrin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

Membrane topology of gamma-secretase component PEN-2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

Identification of signal peptide peptidase, a presenilin-type aspartic protease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3122203

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

8 July 2018

1 reference

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The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances

8 July 2018

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8 July 2018

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Helical membrane proteins: diversity of functions in the context of simple architecture

8 July 2018

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The tandem affinity purification (TAP) method: a general procedure of protein complex purification

8 July 2018

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8 July 2018

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8 July 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

8 July 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

8 July 2018

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8 July 2018

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8 July 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

8 July 2018

1 reference

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The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

8 July 2018

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8 July 2018

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Mutant genes in familial Alzheimer's disease and transgenic models

8 July 2018

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8 July 2018

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

8 July 2018

1 reference

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SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

8 July 2018

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8 July 2018

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8 July 2018

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Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

8 July 2018

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8 July 2018

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Crystal structure of a rhomboid family intramembrane protease.

21 January 2018

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Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

27 September 2018

1 reference

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Nicastrin functions as a gamma-secretase-substrate receptor

27 September 2018

1 reference

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Average protein density is a molecular-weight-dependent function.

27 September 2018

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The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

27 September 2018

1 reference

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Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

27 September 2018

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The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

27 September 2018

1 reference

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

27 September 2018

1 reference

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Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

27 September 2018

1 reference

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Reconstitution of gamma-secretase activity

27 September 2018

1 reference

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Genetic neurodegenerative diseases: the human illness and transgenic models

27 September 2018

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A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.193326

Xmipp: An Image Processing Package for Electron Microscopy

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.193326

21 January 2018

Identifiers

DOI

10.1074/JBC.M110.193326

1 reference

6 August 2017

1 reference

6 August 2017

1 reference