Hedgehog pathway agonism: therapeutic potential and small-molecule development (Q35033925)

5 August 2017

Hedgehog pathway agonism: therapeutic potential and small-molecule development (English)

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5 August 2017

M Kyle Hadden

1

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5 August 2017

7 November 2013

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5 August 2017

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5 August 2017

9

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5 August 2017

27-37

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5 August 2017

1

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Mechanisms and functions of Hedgehog signalling across the metazoa

5 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog: functions and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling pathway in neural development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

A review of hedgehog signaling in cranial bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Wnt and hedgehog signaling pathways in bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

The hedgehog pathway and neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic Hedgehog signaling in the mammalian brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Cooperative effects of Sonic Hedgehog and NGF on basal forebrain cholinergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

The structural and functional integrity of peripheral nerves depends on the glial-derived signal desert hedgehog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Brain-derived neurotrophic factor facilitates maturation of mesenchymal stem cell-derived dopamine progenitors to functional neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog is cytoprotective against oxidative challenge in a cellular model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog signaling is essential for hair development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling plays a conserved role in inhibiting fat formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog morphogen in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling in murine vasculogenesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

The Hedgehog morphogen in myocardial ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling is essential for endothelial tube formation during vasculogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Recombinant human sonic hedgehog protein regulates the expression of ZO-1 and occludin by activating angiopoietin-1 in stroke damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Multiple roles for lipids in the Hedgehog signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

The hedgehog receptor patched is involved in cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fat

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Oxysterols are allosteric activators of the oncoprotein Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Roughing up Smoothened: chemical modulators of hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Small molecule modulation of Smoothened activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Potent agonists of the Hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Directed differentiation of embryonic stem cells into motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Self-formation of functional adenohypophysis in three-dimensional culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Differentiation of spinal motor neurons from pluripotent human stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Molecular pathways: the hedgehog signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Targeting the Hedgehog signaling pathway for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

7 January 2021

Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

7 January 2021

Essential role for Sonic hedgehog during hair follicle morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

7 January 2021

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

7 January 2021

Novel oxysterols activate the Hedgehog pathway and induce osteogenesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201300358

7 January 2021

Identifiers

DOI

10.1002/CMDC.201300358

1 reference

5 August 2017

1 reference

PubMed ID

24203435