Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. (Q34684014)

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English	Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration.	scientific article

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1 January 2020

Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration (English)

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1 January 2020

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Parkinson's disease

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

Maria G. Castro

5

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1 January 2020

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A Hurtado-Lorenzo

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E Millan

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1 January 2020

V Gonzalez-Nicolini

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D Suwelack

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P R Lowenstein

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1 September 2004

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Molecular Therapy

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3

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507-524

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1 January 2020

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

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Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats.

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7 July 2018

Gene therapy progress and prospects: Parkinson's disease

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7 July 2018

Neuroprotective strategies in Parkinson's disease : an update on progress

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7 July 2018

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7 July 2018

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Sonic hedgehog and FGF8 collaborate to induce dopaminergic phenotypes in the Nurr1-overexpressing neural stem cell

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7 July 2018

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

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Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system

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7 July 2018

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

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7 July 2018

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer

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7 July 2018

Overexpression of midbrain-specific transcription factor Nurr1 modifies susceptibility of mouse neural stem cells to neurotoxins

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7 July 2018

Behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets.

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7 July 2018

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7 July 2018

Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease

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7 July 2018

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem

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7 July 2018

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7 July 2018

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7 July 2018

Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line.

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7 July 2018

Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration

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7 July 2018

Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses

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7 July 2018

Protection by synergistic effects of adenovirus-mediated X-chromosome-linked inhibitor of apoptosis and glial cell line-derived neurotrophic factor gene transfer in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

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7 July 2018

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

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7 July 2018

Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1

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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat.

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Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum

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Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

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7 July 2018

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Expression of neurturin, GDNF, and their receptors in the adult mouse CNS.

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Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

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Human Adenovirus Vectors for Gene Transfer into Mammalian Cells

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Dopamine neuron agenesis in Nurr1-deficient mice

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7 July 2018

Dopaminergic neurons protected from degeneration by GDNF gene therapy

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7 July 2018

GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine.

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Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1

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Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

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7 July 2018

Biochemical evidence that patched is the Hedgehog receptor

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7 July 2018

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

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Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system

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7 July 2018

Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development

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7 July 2018

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.

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7 July 2018

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

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7 July 2018

A high percentage yield of tyrosine hydroxylase-positive cells from rat E14 mesencephalic cell culture

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7 July 2018

The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands

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The adult substantia nigra contains progenitor cells with neurogenic potential.

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26 October 2018

Sonic Hedgehog signalling in the developing and adult brain

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26 October 2018

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26 October 2018

Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system.

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26 October 2018

Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice

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Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors

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26 October 2018

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

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Adenoviral vectors as functional retrograde neuronal tracers

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Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

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Induction of midbrain dopaminergic neurons by Sonic hedgehog

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1479772

26 October 2018

Sonic Hedgehog Promotes the Survival of Specific CNS Neuron Populations and Protects These Cells from Toxic InsultIn Vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.05.021

7 January 2021

Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.05.021

7 January 2021

Smartbombs and cloaking devices

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.05.021

7 January 2021

Identifiers

10.1016/J.YMTHE.2004.05.021

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15336651%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15336651%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15336651%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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