20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans (Q35039312)

5 August 2017

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans (English)

1 reference

5 August 2017

Caenorhabditis elegans

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1 reference

Nektarios Tavernarakis

4

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5 August 2017

Niki Chondrogianni

1

1 reference

5 August 2017

Konstantina Georgila

2

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5 August 2017

Nikos Kourtis

3

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5 August 2017

Efstathios S Gonos

5

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5 August 2017

language of work or name

English

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publication date

13 November 2014

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5 August 2017

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5 August 2017

29

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5 August 2017

2

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5 August 2017

611-622

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describes a project that uses

5 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4314225/fullTextXML

inferred from PubMed Central ID database lookup

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Degradation of damaged proteins: the main function of the 20S proteasome

8 July 2018

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8 July 2018

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EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan

8 July 2018

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Variable pathogenicity determines individual lifespan in Caenorhabditis elegans

8 July 2018

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8 July 2018

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Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

8 July 2018

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Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

8 July 2018

1 reference

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Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

8 July 2018

1 reference

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A conserved ubiquitination pathway determines longevity in response to diet restriction

8 July 2018

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AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model

8 July 2018

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Proteasomal regulation of the hypoxic response modulates aging in C. elegans

8 July 2018

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The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans

8 July 2018

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

8 July 2018

1 reference

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Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Dysfunction of the ubiquitin-proteasome system in multiple disease conditions: therapeutic approaches

8 July 2018

1 reference

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Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator

8 July 2018

1 reference

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Puzzles, promises and a cure for ageing

8 July 2018

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Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status

8 July 2018

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Proteasome activation as a novel antiaging strategy

8 July 2018

1 reference

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Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

8 July 2018

1 reference

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

8 July 2018

1 reference

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Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

8 July 2018

1 reference

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Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells

8 July 2018

1 reference

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Two neurons mediate diet-restriction-induced longevity in C. elegans

8 July 2018

1 reference

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Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

8 July 2018

1 reference

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Cytoprotective effects of proteasome beta5 subunit overexpression in lens epithelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome?

8 July 2018

1 reference

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The plasticity of aging: insights from long-lived mutants

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Selective degradation of oxidatively modified protein substrates by the proteasome.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Analysis of Drosophila 26 S proteasome using RNA interference

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Degradation of oxidized proteins in mammalian cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Interacting genes in nematode dauer larva formation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Temporal requirements of heat shock factor-1 for longevity assurance

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

SMK-1, an essential regulator of DAF-16-mediated longevity

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

DAF-16 target genes that control C. elegans life-span and metabolism.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4314225

Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model

25 October 2018

1 reference

12 December 2020

Fibroblast cultures from healthy centenarians have an active proteasome

1 reference

12 December 2020

Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates

1 reference

12 December 2020

Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans

1 reference

12 December 2020

Identifiers

DOI

10.1096/FJ.14-252189

1 reference

release_4bert5dcmjfflfv3262uv6zigq

5 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4bert5dcmjfflfv3262uv6zigq

24 November 2022

mapped directly with Wikidata item

PMCID

4314225

1 reference

5 August 2017

1 reference