Cdk5 as a drug target for the treatment of Alzheimer's disease (Q35050281)

6 August 2017

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title

Cdk5 as a drug target for the treatment of Alzheimer's disease (English)

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6 August 2017

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Lit-Fui Lau

1

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6 August 2017

Patricia A Seymour

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2

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6 August 2017

Mark A Sanner

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3

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6 August 2017

Joel B Schachter

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4

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6 August 2017

1 December 2002

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Journal of Molecular Neuroscience

6 August 2017

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6 August 2017

19

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6 August 2017

267-273

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6 August 2017

3

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https://scigraph.springernature.com/pub.10.1385/jmn:19:3:267

6 August 2017

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cites work

Tyrosine kinase inhibitors-ZD1839 (Iressa).

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12 December 2020

Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse

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12 December 2020

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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12 December 2020

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system.

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12 December 2020

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

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12 December 2020

An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator

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12 December 2020

Cdk5 behind the wheel: a role in trafficking and transport?

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12 December 2020

Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.

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12 December 2020

Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

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12 December 2020

Tau protein phosphorylation as a therapeutic target in Alzheimer's disease

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12 December 2020

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

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12 December 2020

Transgenic mouse models of tauopathies: prospects for animal models of Pick's disease

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12 December 2020

Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly

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12 December 2020

Progress in the modeling of neurodegenerative diseases in transgenic mice

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12 December 2020

reply: Neurobiologyp25 protein in neurodegeneration

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12 December 2020

Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity

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12 December 2020

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

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12 December 2020

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

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12 December 2020

Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth

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12 December 2020

Rapid reversible phosphorylation of rat brain tau proteins in response to cold water stress

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12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

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12 December 2020

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

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12 December 2020

Cyclin-dependent kinase 5 promotes insulin exocytosis.

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12 December 2020

A brain-specific activator of cyclin-dependent kinase 5.

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

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12 December 2020

Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems

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12 December 2020

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

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12 December 2020

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

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12 December 2020

Integrin alpha(1) beta(1)-mediated activation of cyclin-dependent kinase 5 activity is involved in neurite outgrowth and human neurofilament protein H Lys-Ser-Pro tail domain phosphorylation.

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12 December 2020

tau kinases in the rat heat shock model: possible implications for Alzheimer disease

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12 December 2020

A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal Cdk5 activator

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12 December 2020

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

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12 December 2020

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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12 December 2020

Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry

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12 December 2020

Tau and transgenic animal models

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12 December 2020

Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains.

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12 December 2020

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

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12 December 2020

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12 December 2020

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12 December 2020

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

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12 December 2020

The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease

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12 December 2020

Analysis of tauopathies with transgenic mice

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12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

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12 December 2020

The crystal structure of cyclin A

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12 December 2020

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

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12 December 2020

Cdk5/p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity.

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12 December 2020

Sites of phosphorylation in tau and factors affecting their regulation.

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12 December 2020

Identifiers

DOI

10.1385/JMN:19:3:267

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Dimensions Publication ID

6 August 2017

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