Cell stress-associated caspase activation: intrinsically complex? (Q35092336)

6 August 2017

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title

Cell stress-associated caspase activation: intrinsically complex? (English)

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6 August 2017

Emma M Creagh

1

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PubMed ID

12657730

6 August 2017

Seamus J Martin

series ordinal

2

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6 August 2017

25 March 2003

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Science's STKE : signal transduction knowledge environment

6 August 2017

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6 August 2017

2003

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6 August 2017

175

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6 August 2017

pe11

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

6 August 2017

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Cell death: the significance of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Programmed cell death in animal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Protease activation during apoptosis: death by a thousand cuts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase structure, proteolytic substrates, and function during apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Serial killers: ordering caspase activation events in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Mechanisms of caspase activation and inhibition during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The mitochondrial apoptosome: a killer unleashed by the cytochrome seas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase-9 and APAF-1 form an active holoenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Interdigital cell death can occur through a necrotic and caspase-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

BCL-2 family members and the mitochondria in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Breaking the mitochondrial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The mitochondrion in apoptosis: how Pandora's box opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Adult Apaf-1-deficient mice exhibit male infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase knockouts: matters of life and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Defects in regulation of apoptosis in caspase-2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

The proteolytic procaspase activation network: an in vitro analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

RAIDD is a new 'death' adaptor molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

A novel Apaf-1-independent putative caspase-2 activation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Apoptosis. A cinderella caspase takes center stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

Pinocytic loading of cytochrome c into intact cells specifically induces caspase-dependent permeabilization of mitochondria: evidence for a cytochrome c feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2003.175.PE11

10.1126/STKE.2003.175.PE11

21 January 2018

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12657730