A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis (Q35093044)

6 August 2017

A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis (English)

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6 August 2017

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Kristine L Stump

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6 August 2017

Lily D Lu

2

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6 August 2017

Pawel Dobrzanski

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6 August 2017

Cynthia Serdikoff

4

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6 August 2017

Diane E Gingrich

5

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6 August 2017

Ben J Dugan

6

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6 August 2017

Thelma S Angeles

7

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6 August 2017

Mark S Albom

8

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6 August 2017

Mark A Ator

9

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6 August 2017

Bruce D Dorsey

10

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6 August 2017

Bruce A Ruggeri

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6 August 2017

Matthew M Seavey

12

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6 August 2017

21 April 2011

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Arthritis Research and Therapy

6 August 2017

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6 August 2017

13

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6 August 2017

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6 August 2017

R68

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https://scigraph.springernature.com/pub.10.1186/ar3329

6 August 2017

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cites work

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B cell therapies for rheumatoid arthritis: beyond B cell depletion

9 July 2018

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Therapeutic antibodies for autoimmunity and inflammation

9 July 2018

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Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050.

9 July 2018

1 reference

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Nonresolving inflammation

9 July 2018

1 reference

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Kinase inhibitors: a new approach to rheumatoid arthritis treatment

9 July 2018

1 reference

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Dermatological complications and safety of anti-TNF treatments

9 July 2018

1 reference

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SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling

9 July 2018

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CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders

9 July 2018

1 reference

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The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis.

9 July 2018

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9 July 2018

Anti-TNF-induced lupus

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An anti-vascular endothelial growth factor receptor 2/fetal liver kinase-1 Listeria monocytogenes anti-angiogenesis cancer vaccine for the treatment of primary and metastatic Her-2/neu+ breast tumors in a mouse model.

9 July 2018

1 reference

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Tocilizumab: a review of its use in the management of rheumatoid arthritis

9 July 2018

1 reference

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Fostamatinib, a Syk inhibitor prodrug for the treatment of inflammatory diseases

9 July 2018

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Interleukin-6 as a key player in systemic inflammation and joint destruction.

9 July 2018

1 reference

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Autoimmune diseases induced by TNF-targeted therapies

9 July 2018

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Emerging therapeutics for rheumatoid arthritis.

9 July 2018

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Inflammation: gearing the journey to cancer

9 July 2018

1 reference

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Carrageenan-induced acute inflammation in the mouse air pouch synovial model. Role of tumour necrosis factor.

9 July 2018

1 reference

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Cytokine signaling modules in inflammatory responses

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

A quantitative analysis of kinase inhibitor selectivity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Cytokines in the pathogenesis of rheumatoid arthritis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3 receptor activation in thioglycollate-induced peritonitis.

9 July 2018

1 reference

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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

A small molecule-kinase interaction map for clinical kinase inhibitors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

A quantitative study of decalcification methods in histology

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Stat3 activation by Src induces specific gene regulation and is required for cell transformation

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Interleukin 6 is required for the development of collagen-induced arthritis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Rapid demineralization in acidic buffers

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3132063

Kinase inhibitors attract attention as oral rheumatoid arthritis drugs.

9 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FAR3329

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FAR3329

Activation of the transcription factor NF-kappaB in the rat air pouch model of inflammation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2FAR3329

Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma

21 January 2018

1 reference

12 December 2020

Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice

1 reference

12 December 2020

Modulation of collagen-induced arthritis by IL-4 and dexamethasone: the synergistic effect of IL-4 and dexamethasone on the resolution of CIA

1 reference

12 December 2020

The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis

1 reference

12 December 2020

Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy

1 reference

12 December 2020

The expression of SOCS is altered in rheumatoid arthritis

1 reference

12 December 2020

Association of pepsin with type II collagen (CII) breaks control of CII autoimmunity and triggers development of arthritis in rats

1 reference

12 December 2020

The Jak-STAT pathway in rheumatoid arthritis

1 reference

12 December 2020

The mouse model of collagen-induced arthritis

1 reference

12 December 2020

Identifiers

DOI

10.1186/AR3329

1 reference

Dimensions Publication ID

6 August 2017

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1 reference

6 August 2017

1 reference