Fumarate induces redox-dependent senescence by modifying glutathione metabolism (Q35121732)

6 August 2017

Fumarate induces redox-dependent senescence by modifying glutathione metabolism (English)

1 reference

6 August 2017

1 reference

Karen Blyth

14

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RuAngelie Edrada-Ebel

RuAngelie Edrada-Ebel

10

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Eyal Gottlieb

Eyal Gottlieb

17

0 references

Christian Frezza

Christian Frezza

16

0 references

Eytan Ruppin

15

Eytan Ruppin

1 reference

6 August 2017

Liang Zheng

1

1 reference

6 August 2017

Simone Cardaci

2

1 reference

6 August 2017

Livnat Jerby

3

1 reference

6 August 2017

Elaine D MacKenzie

4

1 reference

6 August 2017

Marco Sciacovelli

5

1 reference

6 August 2017

T Isaac Johnson

6

1 reference

6 August 2017

Edoardo Gaude

7

1 reference

6 August 2017

Ayala King

8

1 reference

6 August 2017

Joshua D G Leach

9

1 reference

6 August 2017

Ann Hedley

11

1 reference

6 August 2017

Nicholas A Morrice

12

1 reference

6 August 2017

Gabriela Kalna

13

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6 August 2017

language of work or name

English

0 references

publication date

23 January 2015

1 reference

6 August 2017

Nature Communications

1 reference

6 August 2017

6

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6 August 2017

6001

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Creative Commons Attribution 4.0 International

6 August 2017

start time

23 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms7001

0 references

cites work

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

9 July 2018

1 reference

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

9 July 2018

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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma

9 July 2018

1 reference

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

9 July 2018

1 reference

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Predicting selective drug targets in cancer through metabolic networks.

9 July 2018

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Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

9 July 2018

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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect

9 July 2018

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Inborn and acquired metabolic defects in cancer

9 July 2018

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Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer

9 July 2018

1 reference

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Nrf2:INrf2 (Keap1) signaling in oxidative stress

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

9 July 2018

1 reference

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Immortalized mouse epithelial cell models to study the role of apoptosis in cancer

9 July 2018

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Cellular senescence in cancer and aging

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Global reconstruction of the human metabolic network based on genomic and bibliomic data

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Mitochondrial tumour suppressors: a genetic and biochemical update

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

BRAFE600-associated senescence-like cell cycle arrest of human naevi

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

The effects of alternate optimal solutions in constraint-based genome-scale metabolic models

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Putting the stress on senescence

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Gene ontology: tool for the unification of biology

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

The Ki-67 protein: from the known and the unknown

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4340546

The extended catalysis of glutathione transferase

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS7001

iMAT: an integrative metabolic analysis tool

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25613188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Network-based prediction of human tissue-specific metabolism

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25613188

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS7001

1 reference

6 August 2017

0 references

1 reference

6 August 2017

1 reference