Inhibition of lactate dehydrogenase activity as an approach to cancer therapy (Q35122361)

6 August 2017

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title

Inhibition of lactate dehydrogenase activity as an approach to cancer therapy (English)

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6 August 2017

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Giuseppina Di Stefano

series ordinal

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Luigi Fiume

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Marina Vettraino

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

1 March 2014

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Future Medicinal Chemistry

6 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

429-445

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

Molecular evolution within the L-malate and L-lactate dehydrogenase super-family

10 June 2020

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Partial purification and characterization of lactate dehydrogenase from Plasmodium falciparum

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Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites

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Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies

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Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase.

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Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation

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Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs.

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Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase

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Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase.

21 January 2018

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Lactate: a major product of glutamine metabolism by human diploid fibroblasts

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Mitochondria and L-lactate metabolism.

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Cell-cell and intracellular lactate shuttles.

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Mechanisms for redox control of gene expression

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The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

21 January 2018

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Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase.

21 January 2018

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L-lactate dehydrogenase A4- and A3B isoforms are bona fide peroxisomal enzymes in rat liver. Evidence for involvement in intraperoxisomal NADH reoxidation

21 January 2018

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Peroxisomal membrane monocarboxylate transporters: evidence for a redox shuttle system?

21 January 2018

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Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments

21 January 2018

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Food for thought: challenging the dogmas

21 January 2018

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Energy transfer from astrocytes to axons: the role of CNS glycogen

21 January 2018

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Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle

21 January 2018

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Mitochondrial lactate dehydrogenase is involved in oxidative-energy metabolism in human astrocytoma cells (CCF-STTG1).

21 January 2018

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Immunoreactive helix-destabilizing protein localized in transcriptionally active regions of Drosophila polytene chromosomes

21 January 2018

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Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5.

21 January 2018

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Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-alpha-primase complex

21 January 2018

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Identification of the mouse low-salt-eluting single-stranded DNA-binding protein as a mammalian lactate dehydrogenase-A isoenzyme

21 January 2018

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Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status

21 January 2018

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Integration of the metabolic/redox state, histone gene switching, DNA replication and S-phase progression by moonlighting metabolic enzymes.

21 January 2018

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Minimal functional unit of lactate dehydrogenase.

21 January 2018

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Nuclear localization of a lactic dehydrogenase with single-stranded DNA-binding properties.

21 January 2018

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Causes and consequences of increased glucose metabolism of cancers

21 January 2018

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The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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The engine driving the ship: metabolic steering of cell proliferation and death.

21 January 2018

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Evidence for an alternative glycolytic pathway in rapidly proliferating cells

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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MYC-induced cancer cell energy metabolism and therapeutic opportunities

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.206

Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy

21 January 2018

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Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms

21 January 2018

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Acidity generated by the tumor microenvironment drives local invasion

21 January 2018

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

21 January 2018

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A unique glucose-dependent apoptotic pathway induced by c-Myc

21 January 2018

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Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

21 January 2018

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Glycolysis inhibition for anticancer treatment

21 January 2018

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Targeting metabolic transformation for cancer therapy.

21 January 2018

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Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.

21 January 2018

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Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

21 January 2018

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Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

21 January 2018

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Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors

21 January 2018

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

21 January 2018

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Molecular characterization of gene expression in human lactate dehydrogenase-A deficiency

21 January 2018

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Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency

21 January 2018

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Molecular genetic studies of muscle lactate dehydrogenase deficiency in white patients

21 January 2018

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A missense mutation found in human lactate dehydrogenase-B (H) variant gene

21 January 2018

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A novel missense mutation in human lactate dehydrogenase B-subunit gene

21 January 2018

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Lactate dehydrogenase M-subunit deficiency: a new type of hereditary exertional myopathy

21 January 2018

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The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.206

Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

LDH-A influences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.206

Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Lactate dehydrogenase-B is silenced by promoter methylation in a high frequency of human breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Investigations on gossypol: past and present developments

21 January 2018

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Enzyme inactivation and inhibition by gossypol

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.206

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

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A validated HPLC assay for the determination of R-(-)-gossypol in human plasma and its application in clinical pharmacokinetic studies

21 January 2018

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Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

21 January 2018

1 reference

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Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

21 January 2018

1 reference

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Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Fragment-based lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Targeting glycolysis: a fragment based approach towards bifunctional inhibitors of hLDH-5.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.206

A general method for relieving substrate inhibition in lactate dehydrogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Source of Catalysis in the Lactate Dehydrogenase System. Ground-State Interactions in the Enzyme.cntdot.Substrate Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Design, Synthesis, and Biological Evaluation ofPlasmodium falciparumLactate Dehydrogenase Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

Inhibition of Aerobic Glycolysis in Yoshida Ascites Hepatoma by Tartronic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.206

21 January 2018

Identifiers

DOI

10.4155/FMC.13.206

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24635523%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference