Targeting lung cancer through inhibition of checkpoint kinases (Q35128547)

25774168

6 August 2017

title

Targeting lung cancer through inhibition of checkpoint kinases (English)

1 reference

6 August 2017

1 reference

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Randi G Syljuåsen

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Grete Hasvold

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Sissel Hauge

series ordinal

3

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6 June 2020

publication date

27 February 2015

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25774168

6 August 2017

published in

Frontiers in Genetics

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6 June 2020

volume

6

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6 June 2020

page(s)

70

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Prevalence and natural history of ALK positive non-small-cell lung cancer and the clinical impact of targeted therapy with ALK inhibitors

6 June 2020

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ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

28 July 2018

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CHK1 levels correlate with sensitization to pemetrexed by CHK1 inhibitors in non-small cell lung cancer cells

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy

28 July 2018

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RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

28 July 2018

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Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties

28 July 2018

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

28 July 2018

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

28 July 2018

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Targeting Hypoxic Cells through the DNA Damage Response

28 July 2018

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In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

28 July 2018

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28 July 2018

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Down-regulation of Wee1 kinase by a specific subset of microRNA in human sporadic pituitary adenomas

28 July 2018

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Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer.

28 July 2018

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Abrogation of the G2 checkpoint by inhibition of Wee-1 kinase results in sensitization of p53-deficient tumor cells to DNA-damaging agents

28 July 2018

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Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress

28 July 2018

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Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

28 July 2018

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CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines.

28 July 2018

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Comparative analysis of DNA repair in stem and nonstem glioma cell cultures

28 July 2018

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28 July 2018

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The impact of O2 availability on human cancer

28 July 2018

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An oncogene-induced DNA damage model for cancer development

28 July 2018

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Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

28 July 2018

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Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint

28 July 2018

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Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

28 July 2018

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Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells

28 July 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

28 July 2018

1 reference

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Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development

28 July 2018

1 reference

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Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

28 July 2018

1 reference

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

28 July 2018

1 reference

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Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing Radiation.

28 July 2018

1 reference

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Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation

28 July 2018

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Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

28 July 2018

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Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Hypoxia links ATR and p53 through replication arrest

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

p53: a frequent target for genetic abnormalities in lung cancer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Review of EGFR TKIs in Metastatic NSCLC, Including Ongoing Trials

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

ATR inhibition preferentially targets homologous recombination-deficient tumor cells.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Targeted therapies in non-small cell lung cancer: emerging oncogene targets following the success of epidermal growth factor receptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Cancer stem cells: A contentious hypothesis now moving forward.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

CHK1 and WEE1 inhibition combine synergistically to enhance therapeutic efficacy in acute myeloid leukemia ex vivo.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Tumor hypoxia as a driving force in genetic instability.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

CHEK again: revisiting the development of CHK1 inhibitors for cancer therapy

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Chk1 knockdown confers radiosensitization in prostate cancer stem cells

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Integrated functional, gene expression and genomic analysis for the identification of cancer targets

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343027

Amplification and expression of the c-myc oncogene in human lung cancer cell lines

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.3389%2FFGENE.2015.00070

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25774168

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25774168

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The clinical significance of Cyclin B1 and Wee1 expression in non-small-cell lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25774168

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FGENE.2015.00070

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

25774168

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25774168%20AND%20SRC:MED&resulttype=core&format=json