The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release. (Q35172714)

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29 February 2020

title

The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release (English)

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29 February 2020

0 references

12

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7

Gary D V Hankins

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29 February 2020

author name string

Serena C Hedgepeth

1

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M Iveth Garcia

2

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Larry E Wagner

3

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Ana M Rodriguez

4

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Sree V Chintapalli

5

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29 February 2020

Russell R Snyder

6

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Beric R Henderson

8

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Kirsty M Brodie

9

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David I Yule

10

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29 February 2020

Damian B van Rossum

11

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language of work or name

English

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publication date

2 February 2015

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Journal of Biological Chemistry

29 February 2020

published in

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volume

290

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issue

11

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29 February 2020

page(s)

7304-7313

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Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells

29 February 2020

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Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.

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Targeting Bcl-2 based on the interaction of its BH4 domain with the inositol 1,4,5-trisphosphate receptor.

13 July 2018

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BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis

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NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area.

13 July 2018

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A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways

13 July 2018

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Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria

13 July 2018

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BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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27 September 2018

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27 September 2018

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Decoding of cytosolic calcium oscillations in the mitochondria

27 September 2018

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12 December 2020

Location of BRCA1 in human breast and ovarian cancer cells

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12 December 2020

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Histamine-evoked Ca2+ oscillations in HeLa cells are sensitive to methylxanthines but insensitive to ryanodine

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Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.611186

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25645916%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

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29 February 2020

PubMed publication ID

25645916

1 reference