Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB (Q35176553)

6 August 2017

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB (English)

1 reference

6 August 2017

3

1 reference

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3 June 2020

Francois Verrey

6

1 reference

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3 June 2020

author name string

Thomas Eicher

1

1 reference

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3 June 2020

Markus A Seeger

2

1 reference

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3 June 2020

Wenchang Zhou

4

1 reference

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3 June 2020

Lorenz Brandstätter

5

1 reference

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3 June 2020

Kay Diederichs

7

1 reference

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3 June 2020

José D Faraldo-Gómez

8

1 reference

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3 June 2020

Klaas M Pos

9

1 reference

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3 June 2020

language of work or name

English

0 references

publication date

19 September 2014

1 reference

6 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25248080%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

3

1 reference

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

3 June 2020

cites work

1 reference

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Structure of the AcrAB–TolC multidrug efflux pump

28 July 2018

1 reference

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GRIFFIN: A versatile methodology for optimization of protein-lipid interfaces for membrane protein simulations.

28 July 2018

1 reference

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Protein dielectric constants determined from NMR chemical shift perturbations

28 July 2018

1 reference

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Structural basis for the inhibition of bacterial multidrug exporters

28 July 2018

1 reference

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Subangstrom Resolution X-Ray Structure Details Aquaporin-Water Interactions

28 July 2018

1 reference

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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

28 July 2018

1 reference

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Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

28 July 2018

1 reference

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Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria

28 July 2018

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

28 July 2018

1 reference

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Conformational relaxation and water penetration coupled to ionization of internal groups in proteins

28 July 2018

1 reference

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Features and development of Coot

28 July 2018

1 reference

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Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

PHENIX: a comprehensive Python-based system for macromolecular structure solution

28 July 2018

1 reference

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28 July 2018

1 reference

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Molecular replacement with MOLREP

28 July 2018

1 reference

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Improved prediction of protein side-chain conformations with SCWRL4

28 July 2018

1 reference

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Phasercrystallographic software

28 July 2018

1 reference

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CHARMM: the biomolecular simulation program

28 July 2018

1 reference

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Crucial role of Asp408 in the proton translocation pathway of multidrug transporter AcrB: evidence from site-directed mutagenesis and carbodiimide labeling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Drug transport mechanism of the AcrB efflux pump

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Threonine-978 in the transmembrane segment of the multidrug efflux pump AcrB of Escherichia coli is crucial for drug transport as a probable component of the proton relay network

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Conformational flexibility in the multidrug efflux system protein AcrA.

28 July 2018

1 reference

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Scalable molecular dynamics with NAMD

28 July 2018

1 reference

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The NPC1 protein: structure implies function.

28 July 2018

1 reference

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Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.

28 July 2018

1 reference

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Multidrug-exporting secondary transporters

28 July 2018

1 reference

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Function of the MexB efflux-transporter divided into two halves

28 July 2018

1 reference

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Crystal structure of bacterial multidrug efflux transporter AcrB

28 July 2018

1 reference

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Patched acts catalytically to suppress the activity of Smoothened

28 July 2018

1 reference

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The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins.

28 July 2018

1 reference

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

28 July 2018

1 reference

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The ATP synthase--a splendid molecular machine

28 July 2018

1 reference

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Reduced surface: an efficient way to compute molecular surfaces

28 July 2018

1 reference

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VMD: visual molecular dynamics

28 July 2018

1 reference

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AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Molecular mechanics models for tetracycline analogs

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Improved treatment of the protein backbone in empirical force fields.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Purification, crystallization and preliminary diffraction studies of AcrB, an inner-membrane multi-drug efflux protein

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Identification of essential charged residues in transmembrane segments of the multidrug transporter MexB of Pseudomonas aeruginosa

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels

27 September 2018

1 reference

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Three ways in, one way out: water dynamics in the trans-membrane domains of the inner membrane translocase AcrB

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359379

27 September 2018

Identifiers

DOI

10.7554/ELIFE.03145

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25248080%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25248080%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference