Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma (Q35186648)

7 August 2017

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title

Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma (English)

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7 August 2017

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Kirk M Druey

1

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7 August 2017

language of work or name

English

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publication date

1 August 2003

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Expert Opinion on Therapeutic Targets

7 August 2017

published in

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7 August 2017

volume

7

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7 August 2017

issue

4

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7 August 2017

page(s)

475-484

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Regulation of mast-cell and basophil function and survival by IgE.

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Mast-cell infiltration of airway smooth muscle in asthma.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Asthma: an epidemic of dysregulated immunity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

The bronchial epithelium in chronic and severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Airway remodeling in the pathogenesis of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Chemokines and cell migration in secondary lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Chemokines and their role in airway hyper-reactivity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Non-redundant functional groups of chemokines operate in a coordinate manner during the inflammatory response in the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Chemokines as regulators of T cell differentiation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Role of chemokines in the pathogenesis of asthma

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Regulation of the inflammatory response in asthma by mast cell products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Role of tachykinins in bronchial hyper-responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Nociceptin effects in the airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

21 January 2018

Leukotriene modifiers.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Modelling G-protein-coupled receptors for drug design

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

G proteins: transducers of receptor-generated signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

G-protein-coupled receptors and signaling networks: emerging paradigms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Heterotrimeric G proteins control diverse pathways of transmembrane signaling, a base for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

The role of Rho in G protein-coupled receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Effect of interleukin-1beta and tumor necrosis factor-alpha on the expression of G-proteins in CD4+ T-cells of atopic asthmatic subjects

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Elevated nasal mucosal G protein levels and histamine receptor affinity in a guinea pig model of nasal hyperresponsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

The regulator of G protein signaling family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Regulators of G-protein signalling as new central nervous system drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

G-protein mediated gating of inward-rectifier K+ channels

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

RGS proteins: lessons from the RGS9 subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

G protein selectivity is a determinant of RGS2 function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Prediction and confirmation of a site critical for effector regulation of RGS domain activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.7.4.475

A pertussis toxin-sensitive process controls thymocyte emigration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Investigatory and analytical approaches to differential gene expression profiling in mantle cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Functional characterization of the G protein regulator RGS13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Heterotrimeric G protein signaling: role in asthma and allergic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Distribution of RGS4 mRNA in mouse brain shown by in situ hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Molecular cloning and expression analysis of rat Rgs12 and Rgs14

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Polarity exchange at the interface of regulators of G protein signaling with G protein alpha-subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Cellular regulation of RGS proteins: modulators and integrators of G protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Specific involvement of G proteins in regulation of serum response factor-mediated gene transcription by different receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.7.4.475

21 January 2018

Identifiers

DOI

10.1517/14728222.7.4.475

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7 August 2017

1 reference