Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites (Q35195312)

7 August 2017

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title

Apicoplast fatty acid biosynthesis as a target for medical intervention in apicomplexan parasites (English)

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7 August 2017

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Piotr Gornicki

1

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7 August 2017

1 August 2003

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International Journal for Parasitology

7 August 2017

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7 August 2017

33

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7 August 2017

9

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7 August 2017

885-896

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Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900133-4

PlasmoDB: the Plasmodium genome resource. An integrated database providing tools for accessing, analyzing and mapping expression and sequence data (both finished and unfinished).

7 January 2021

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A kingdom-level phylogeny of eukaryotes based on combined protein data

7 January 2021

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Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery

7 January 2021

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An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii

7 January 2021

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Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

7 January 2021

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Rodent models of malaria in the genomics era.

7 January 2021

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Functional genomic technologies applied to the control of the human malaria parasite, Plasmodium falciparum

7 January 2021

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Metabolic control analysis in drug discovery and disease

7 January 2021

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Human fatty acid synthase: role of interdomain in the formation of catalytically active synthase dimer

7 January 2021

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Recent advances in the search for new anti-coccidial drugs

7 January 2021

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Multi-subunit acetyl-CoA carboxylases

7 January 2021

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A plastid organelle as a drug target in apicomplexan parasites.

7 January 2021

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Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum

7 January 2021

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Genome sequence of the human malaria parasite Plasmodium falciparum

7 January 2021

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Biosynthesis of glycosphingolipids de-novo by the human malaria parasite Plasmodium falciparum

7 January 2021

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The plastid in Apicomplexa: what use is it?

7 January 2021

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7 January 2021

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Fatty acid and lipoic acid biosynthesis in higher plant mitochondria

7 January 2021

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Recent advances in the biosynthesis of plant fatty acids

7 January 2021

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A plastid segregation defect in the protozoan parasite Toxoplasma gondii

7 January 2021

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Lipid biosynthesis as a target for antibacterial agents

7 January 2021

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Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

7 January 2021

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Toxoplasma gondii: transmission, diagnosis and prevention

7 January 2021

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Phylogenetic analysis of the acetyl-CoA carboxylase and 3-phosphoglycerate kinase loci in wheat and other grasses

7 January 2021

1 reference

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Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii

7 January 2021

1 reference

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The carboxyltransferase activity of the apicoplast acetyl-CoA carboxylase of Toxoplasma gondii is the target of aryloxyphenoxypropionate inhibitors

7 January 2021

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Wheat cytosolic acetyl-CoA carboxylase complements an ACC1 null mutation in yeast.

7 January 2021

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

7 January 2021

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Engineering of an active animal fatty acid synthase dimer with only one competent subunit

7 January 2021

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Targeting and subcellular localization of Toxoplasma gondii catalase. Identification of peroxisomes in an apicomplexan parasite.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0020-7519%2803%2900133-4

Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors

7 January 2021

1 reference

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The Plasmodium genome database

7 January 2021

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ToxoDB: accessing the Toxoplasma gondii genome

7 January 2021

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Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

7 January 2021

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Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database

7 January 2021

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Antimalarial drug development and new targets

7 January 2021

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Synthesis of chloroplast galactolipids in apicomplexan parasites

7 January 2021

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Gene transfer to the nucleus and the evolution of chloroplasts

7 January 2021

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Resistance as a tool in the study of old and new drug targets in Toxoplasma

7 January 2021

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Apicomplexan plastids as drug targets

7 January 2021

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Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

7 January 2021

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The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents

7 January 2021

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NONPHOTOSYNTHETIC METABOLISM IN PLASTIDS.

7 January 2021

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Herbicide sensitivity determinant of wheat plastid acetyl-CoA carboxylase is located in a 400-amino acid fragment of the carboxyltransferase domain

7 January 2021

1 reference

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Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

7 January 2021

1 reference

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The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII

7 January 2021

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The apicoplast as an antimalarial drug target

7 January 2021

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Medical need, scientific opportunity and the drive for antimalarial drugs

7 January 2021

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Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa

7 January 2021

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Forty years of bacterial fatty acid synthesis

7 January 2021

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Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?

7 January 2021

1 reference

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Cell invasion by Theileria sporozoites

7 January 2021

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Yeast as a model system to study drugs effective against apicomplexan proteins

7 January 2021

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

7 January 2021

1 reference

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The conceptual basis for a new classification of the coccidia

7 January 2021

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Processing of an apicoplast leader sequence in Plasmodium falciparum and the identification of a putative leader cleavage enzyme

7 January 2021

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Phospholipids in parasitic protozoa.

7 January 2021

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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

7 January 2021

1 reference

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A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum

7 January 2021

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Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway

7 January 2021

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Using small molecules to study big questions in cellular microbiology.

7 January 2021

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Functional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum

7 January 2021

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Progress with parasite plastids

7 January 2021

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An isoleucine/leucine residue in the carboxyltransferase domain of acetyl-CoA carboxylase is critical for interaction with aryloxyphenoxypropionate and cyclohexanedione inhibitors

7 January 2021

1 reference

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Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

7 January 2021

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What is the phylogenetic position of Cryptosporidium?

7 January 2021

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Cryptosporidium parvum appears to lack a plastid genome

7 January 2021

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Deciphering apicoplast targeting signals--feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins

7 January 2021

1 reference

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Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase

7 January 2021

1 reference

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10.1016/S0020-7519(03)00133-4

7 January 2021

Identifiers

DOI

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7 August 2017

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PubMed ID

12906873