Cytochrome P450 3A and their regulation (Q35564329)

8 August 2017

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title

Cytochrome P450 3A and their regulation (English)

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8 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14569421

23 March 2024

1 reference

https://api.crossref.org/works/10.1007/S00210-003-0815-3

23 March 2024

author name string

Oliver Burk

series ordinal

1

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8 August 2017

Leszek Wojnowski

series ordinal

2

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8 August 2017

language of work or name

English

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National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14569421

23 March 2024

publication date

21 October 2003

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full work available at URL

8 August 2017

http://link.springer.com/content/pdf/10.1007/s00210-003-0815-3.pdf

file format

Portable Document Format

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Crossref

DOI

https://api.crossref.org/works/10.1007/S00210-003-0815-3

http://link.springer.com/article/10.1007/s00210-003-0815-3/fulltext.html

23 March 2024

1 reference

https://api.crossref.org/works/10.1007/S00210-003-0815-3

http://link.springer.com/content/pdf/10.1007/s00210-003-0815-3

23 March 2024

1 reference

Crossref

DOI

https://api.crossref.org/works/10.1007/S00210-003-0815-3

Naunyn-Schmiedeberg's Archives of Pharmacology

23 March 2024

published in

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8 August 2017

volume

369

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8 August 2017

issue

1

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8 August 2017

page(s)

105-124

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Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

8 August 2017

cites work

1 reference

12 December 2020

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

1 reference

12 December 2020

Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription

1 reference

12 December 2020

The genetic determinants of the CYP3A5 polymorphism

1 reference

12 December 2020

Pharmacokinetics of nifedipine slow release tablet in Mexican subjects: further evidence for an oxidation polymorphism

1 reference

12 December 2020

Selective expression of CYP3A5 and not CYP3A4 in human blood

1 reference

12 December 2020

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

12 December 2020

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

12 December 2020

Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor.

1 reference

12 December 2020

Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus

1 reference

12 December 2020

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation

1 reference

12 December 2020

CYP3A gene expression in human gut epithelium

1 reference

12 December 2020

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

1 reference

12 December 2020

Detection and analysis of spliced chimeric mRNAs in sequence databanks

1 reference

12 December 2020

The pattern of xenobiotic-metabolizing enzymes in the human pancreas

1 reference

12 December 2020

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

1 reference

12 December 2020

Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen

1 reference

12 December 2020

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

1 reference

12 December 2020

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line

1 reference

12 December 2020

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

1 reference

12 December 2020

Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture

1 reference

12 December 2020

Association of CYP3A4 genotype with treatment-related leukemia

1 reference

12 December 2020

Genetic contribution to variable human CYP3A-mediated metabolism

1 reference

12 December 2020

Expression of cytochrome P 450 3A enzymes in human lung: a combined RT-PCR and immunohistochemical analysis of normal tissue and lung tumours.

1 reference

12 December 2020

Novel detection assay by PCR-RFLP and frequency of the CYP3A5 SNPs, CYP3A5*3 and *6, in a Japanese population

1 reference

12 December 2020

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

1 reference

12 December 2020

Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells

1 reference

12 December 2020

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1 reference

12 December 2020

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

1 reference

12 December 2020

An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes

1 reference

12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

1 reference

12 December 2020

C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation

1 reference

12 December 2020

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies

1 reference

12 December 2020

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

12 December 2020

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

1 reference

12 December 2020

Tacrolimus Dosing in Pediatric Heart Transplant Patients is Related to CYP3A5 and MDR1 Gene Polymorphisms

1 reference

12 December 2020

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

12 December 2020

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

1 reference

12 December 2020

No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients

1 reference

12 December 2020

Immunohistochemical localization of cytochrome P450 3A in human pulmonary carcinomas and normal bronchial tissue

1 reference

12 December 2020

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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12 December 2020

Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCP

1 reference

12 December 2020

Genetic polymorphism of cytochrome P450 3A5 in Chinese

1 reference

12 December 2020

Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe

1 reference

12 December 2020

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

1 reference

12 December 2020

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers

1 reference

12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

1 reference

12 December 2020

Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma

1 reference

12 December 2020

Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online

1 reference

12 December 2020

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

1 reference

12 December 2020

Bimodal distribution of renal cytochrome P450 3A activity in humans.

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12 December 2020

Relationship between mRNA levels quantified by reverse transcription-competitive PCR and metabolic activity of CYP3A4 and CYP2E1 in human liver

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12 December 2020

Characterization of cytochrome P450 expression in human oesophageal mucosa.

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12 December 2020

The clinical and economic potential of cyclosporin drug interactions

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12 December 2020

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

1 reference

12 December 2020

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

1 reference

12 December 2020

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

1 reference

12 December 2020

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

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12 December 2020

Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs

1 reference

12 December 2020

Re: Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

12 December 2020

Vitamin E activates gene expression via the pregnane X receptor

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12 December 2020

Induction of cytochromes P450.

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12 December 2020

Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes

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12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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12 December 2020

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.

1 reference

12 December 2020

Metabolism of cytochrome P4503A substrates in vivo administered by the same route: lack of correlation between alfentanil clearance and erythromycin breath test.

1 reference

12 December 2020

Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.

1 reference

12 December 2020

Lopinavir/ritonavir: a review of its use in the management of HIV infection

1 reference

12 December 2020

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

1 reference

12 December 2020

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

1 reference

12 December 2020

Expression of enzymatically active CYP3A4 by Caco-2 cells grown on extracellular matrix-coated permeable supports in the presence of 1alpha,25-dihydroxyvitamin D3.

1 reference

12 December 2020

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

1 reference

12 December 2020

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age

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12 December 2020

Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.

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12 December 2020

Identification of the novel splicing variants for the hPXR in human livers

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12 December 2020

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

1 reference

12 December 2020

Pharmacogenomics: translating functional genomics into rational therapeutics

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12 December 2020

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites

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12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Influence of dietary components on the gastrointestinal metabolism and transport of drugs

1 reference

12 December 2020

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method

1 reference

12 December 2020

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

1 reference

12 December 2020

Expression and localization of CYP3A4 and CYP3A5 in human lung

1 reference

12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

12 December 2020

Pharmacokinetics of oral nifedipine in different populations

1 reference

12 December 2020

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

12 December 2020

Pharmacokinetics of midazolam and 1'-hydroxymidazolam in Chinese with different CYP3A5 genotypes

1 reference

12 December 2020

Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes

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12 December 2020

Dissecting the function of cytochrome P450.

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12 December 2020

Pharmacokinetic drug interactions with antimicrobial agents

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12 December 2020

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

1 reference

12 December 2020

Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies

1 reference

12 December 2020

Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene

1 reference

12 December 2020

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

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12 December 2020

Cytochrome P450 CYP3A5 in the human anterior pituitary gland

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12 December 2020

CYP3A5 variant allele frequencies in Dutch Caucasians

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12 December 2020

In vitro and in vivo drug interactions involving human CYP3A.

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12 December 2020

Phase I and phase II drug-metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium

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12 December 2020

Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans

1 reference

12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.

1 reference

12 December 2020

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

12 December 2020

Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes

1 reference

12 December 2020

Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism

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12 December 2020

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

12 December 2020

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells

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12 December 2020

Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression

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12 December 2020

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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12 December 2020

The distribution and gender difference of CYP3A activity in Chinese subjects

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12 December 2020

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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12 December 2020

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons

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12 December 2020

RESPONSE: re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

12 December 2020

Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.

1 reference

12 December 2020

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

12 December 2020

Common allelic variants of cytochrome P4503A4 and their prevalence in different populations

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12 December 2020

Haplotype blocks and linkage disequilibrium in the human genome

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12 December 2020

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

12 December 2020

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

12 December 2020

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

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12 December 2020

Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity

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12 December 2020

Clinically significant drug interactions with antituberculosis agents

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12 December 2020

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4

1 reference

12 December 2020

Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.

1 reference

12 December 2020

Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

1 reference

12 December 2020

Novel mutations of CYP3A4 in Chinese

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12 December 2020

Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes

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12 December 2020

Identification and functional characterization of eight CYP3A4 protein variants

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12 December 2020

Intergenic mRNA molecules resulting from trans-splicing

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12 December 2020

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

12 December 2020

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

12 December 2020

Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle

1 reference

12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

1 reference

12 December 2020

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

1 reference

12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

12 December 2020

Quantitative RT-PCR for CYP3A4 mRNA in human peripheral lymphocytes: induction of CYP3A4 in lymphocytes and in liver by rifampicin

1 reference

12 December 2020

Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

1 reference

12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

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12 December 2020

The cytochrome P450 3A4 inducer metyrapone is an activator of the human pregnane X receptor

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12 December 2020

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

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12 December 2020

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver

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12 December 2020

Cytochrome P450 regulation by hepatocyte nuclear factor 4 in human hepatocytes: a study using adenovirus-mediated antisense targeting.

1 reference

12 December 2020

In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration

1 reference

12 December 2020

Immunohistochemical study of cytochrome P450 2C and 3A in human non-neoplastic and neoplastic tissues

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12 December 2020

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes

1 reference

12 December 2020

Rapid quantification of CYP3A4 expression in human leukocytes by real-time reverse transcription-PCR

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12 December 2020

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

1 reference

12 December 2020

Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region

1 reference

12 December 2020

Tacrolimus pharmacogenetics: polymorphisms associated with expression of cytochrome p4503A5 and P-glycoprotein correlate with dose requirement

1 reference

12 December 2020

CYP3A4 promoter variant is associated with prostate cancer risk in men with benign prostate hyperplasia.

1 reference

12 December 2020

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

12 December 2020

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

1 reference

12 December 2020

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

1 reference

12 December 2020

Expression of cytochromes P450 in human breast tissue and tumors

1 reference

12 December 2020

Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients.

1 reference

12 December 2020

Ethnic differences in the pharmacokinetics of oral nifedipine

1 reference

12 December 2020

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

1 reference

12 December 2020

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

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12 December 2020

The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer

1 reference

12 December 2020

Re: modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4

1 reference

12 December 2020

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

12 December 2020

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

1 reference

12 December 2020

Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans

1 reference

12 December 2020

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1 reference

12 December 2020

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A.

1 reference

12 December 2020

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

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12 December 2020

Cytochrome P450 CYP3A in human renal cell cancer.

1 reference

12 December 2020

Comparison of the dapsone recovery ratio and the erythromycin breath test as in vivo probes of CYP3A activity in patients with rheumatoid arthritis receiving cyclosporine

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12 December 2020

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

12 December 2020

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

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12 December 2020

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7

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12 December 2020

Substrates of human hepatic cytochrome P450 3A4.

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12 December 2020

Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.

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12 December 2020

Role of cytochrome P450 enzymes in drug-drug interactions.

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12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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12 December 2020

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

1 reference

12 December 2020

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

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12 December 2020

Identifiers

DOI

1 reference

8 August 2017

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