Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis (Q35589281)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17256055%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis (English)

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24 December 2019

7

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24 December 2019

author name string

Lan Mo

1

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24 December 2019

Xiaoyong Zheng

2

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24 December 2019

Hong-Ying Huang

3

1 reference

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24 December 2019

Ellen Shapiro

4

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24 December 2019

Herbert Lepor

5

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24 December 2019

Carlos Cordon-Cardo

6

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24 December 2019

Xue-Ru Wu

8

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24 December 2019

language of work or name

English

0 references

publication date

25 January 2007

1 reference

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Journal of Clinical Investigation

24 December 2019

published in

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24 December 2019

volume

117

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24 December 2019

page(s)

314-325

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24 December 2019

issue

2

1 reference

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Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

24 December 2019

cites work

1 reference

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Mechanisms of Disease: genetic and epigenetic alterations that drive bladder cancer

12 July 2018

1 reference

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

12 July 2018

1 reference

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Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

12 July 2018

1 reference

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

12 July 2018

1 reference

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Urothelial tumorigenesis: a tale of divergent pathways

12 July 2018

1 reference

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Tumour biology: senescence in premalignant tumours

12 July 2018

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Intrinsic tumour suppression

12 July 2018

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12 July 2018

Focus on bladder cancer

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The STATs of cancer--new molecular targets come of age

12 July 2018

1 reference

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p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis.

12 July 2018

1 reference

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Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma

12 July 2018

1 reference

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

12 July 2018

1 reference

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

12 July 2018

1 reference

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Comparative pathology of proliferative lesions of the urinary bladder

12 July 2018

1 reference

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Targeting RAS signalling pathways in cancer therapy

12 July 2018

1 reference

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FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

To cycle or not to cycle: a critical decision in cancer.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Cancer modeling in the modern era: progress and challenges

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

p15(INK4b) in bladder carcinomas: decreased expression in superficial tumours

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

The INK4a/ARF network in tumour suppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Phosphorylation of the PTEN tail regulates protein stability and function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Understanding Ras: 'it ain't over 'til it's over'.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Bladder carcinoma in Costello syndrome: report on a patient born to consanguineous parents and review

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Oncogene amplification in solid tumors

12 July 2018

1 reference

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Essential role for oncogenic Ras in tumour maintenance

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Frequent genetic alterations in simple urothelial hyperplasias of the bladder in patients with papillary urothelial carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Overexpression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

ras activation in human tumors and in animal model systems

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Concurrent mutations of coding and regulatory sequences of the Ha-ras gene in urinary bladder carcinomas

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Oncogene-induced senescence as an initial barrier in lymphoma development

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Cancer: crime and punishment.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

FGFR3 and P53 characterize alternative genetic pathways in the pathogenesis of urothelial cell carcinoma.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

RAS oncogenes: the first 30 years.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Role of the INK4a locus in tumor suppression and cell mortality.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

Mutation Affecting the 12th Amino Acid of the c-Ha- ras Oncogene Product Occurs Infrequently in Human Cancer

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1770948

p53 and RB expression predict progression in T1 bladder cancer

26 September 2018

1 reference

12 December 2020

Natural history and patterns of invasive cancer of the bladder

1 reference

12 December 2020

p16 involvement in primary bladder tumors: analysis of deletions and mutations

1 reference

12 December 2020

Renewal of cell populations in the female mouse

1 reference

12 December 2020

Second case of bladder carcinoma in a patient with Costello syndrome

1 reference

12 December 2020

H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers

1 reference

12 December 2020

Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer

1 reference

12 December 2020

Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation

1 reference

12 December 2020

Recurrent transitional cell carcinoma in a child with the Costello syndrome

1 reference

12 December 2020

Frequent genetic alterations in flat urothelial hyperplasias and concomitant papillary bladder cancer as detected by CGH, LOH, and FISH analyses

1 reference

12 December 2020

Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection

1 reference

12 December 2020

Correlation between the expression of oncogenes ras and c-erbB-2 and the biological behavior of bladder tumors

1 reference

12 December 2020

Genetic alterations in bladder cancer

1 reference

12 December 2020

Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis

1 reference

12 December 2020

Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors

1 reference

12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

1 reference

12 December 2020

Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI30062

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17256055%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17256055%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference