Making sense of mass destruction: quantitating MHC class I antigen presentation (Q35597106)

9 August 2017

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title

Making sense of mass destruction: quantitating MHC class I antigen presentation (English)

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antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway

9 August 2017

main subject

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0002484

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

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Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0002485

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

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Gene Ontology release 2020-05-02

1

Jonathan W Yewdell

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9 August 2017

Eric Reits

2

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9 August 2017

Jacques Neefjes

series ordinal

3

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9 August 2017

publication date

1 December 2003

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Nature Reviews Immunology

9 August 2017

published in

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9 August 2017

volume

3

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9 August 2017

issue

12

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9 August 2017

page(s)

952-961

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Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

9 August 2017

cites work

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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

31 March 2020

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

31 March 2020

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

31 March 2020

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Dynamics of proteasome distribution in living cells

31 March 2020

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The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

31 March 2020

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Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I.

31 March 2020

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ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

31 March 2020

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An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides

31 March 2020

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Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter

31 March 2020

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Powering the peptide pump: TAP crosstalk with energetic nucleotides

31 March 2020

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A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes

31 March 2020

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Impaired immune responses and altered peptide repertoire in tapasin-deficient mice

31 March 2020

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Disulfide bond isomerization and the assembly of MHC class I-peptide complexes

31 March 2020

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26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide

31 March 2020

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Peptide size selection by the major histocompatibility complex-encoded peptide transporter

31 March 2020

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HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides

31 March 2020

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Intracellular transport of membrane glycoproteins: two closely related histocompatibility antigens differ in their rates of transit to the cell surface

31 March 2020

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Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association

31 March 2020

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Protein disulfide isomerase is the dominant acceptor for peptides translocated into the endoplasmic reticulum

31 March 2020

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TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin

31 March 2020

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Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

31 March 2020

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Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling

31 March 2020

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An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope.

31 March 2020

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A proteolytic system that compensates for loss of proteasome function

31 March 2020

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Cells adapted to the proteasome inhibitor 4-hydroxy- 5-iodo-3-nitrophenylacetyl-Leu-Leu-leucinal-vinyl sulfone require enzymatically active proteasomes for continued survival

31 March 2020

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Recycling MHC class I molecules and endosomal peptide loading

31 March 2020

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Antigen loading of MHC class I molecules in the endocytic tract

31 March 2020

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The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

31 March 2020

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The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

31 March 2020

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Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome

31 March 2020

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ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation

31 March 2020

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Dissecting various ATP-dependent steps involved in proteasomal degradation

31 March 2020

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Antigen processing by the proteasome

31 March 2020

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The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation

31 March 2020

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Two new proteases in the MHC class I processing pathway

31 March 2020

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The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues

31 March 2020

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Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation

31 March 2020

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Constitutive display of cryptic translation products by MHC class I molecules

31 March 2020

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Orchestrating nuclear functions: ubiquitin sets the rhythm.

31 March 2020

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The SCF ubiquitin ligase: an extended look

31 March 2020

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Control of enzyme levels in animal tissues

31 March 2020

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Intracellular protein degradation in mammalian and bacterial cells: Part 2

31 March 2020

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Not such a dismal science: the economics of protein synthesis, folding, degradation and antigen processing

31 March 2020

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RMA/S cells present endogenously synthesized cytosolic proteins to class I-restricted cytotoxic T lymphocytes

31 March 2020

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Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein

31 March 2020

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The major substrates for TAP in vivo are derived from newly synthesized proteins

31 March 2020

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Perfect use of imperfection

31 March 2020

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Turnover of nascent proteins in HeLa-S3 cells and the quasi-linear incorporation kinetics of amino acids

31 March 2020

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

31 March 2020

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Detecting and measuring cotranslational protein degradation in vivo

31 March 2020

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.

31 March 2020

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Degradation of CFTR by the ubiquitin-proteasome pathway

31 March 2020

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Neurons promote the translocation of peripheral myelin protein 22 into myelin

31 March 2020

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PMP22 accumulation in aggresomes: implications for CMT1A pathology

31 March 2020

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Association of the thyrotropin receptor with calnexin, calreticulin and BiP. Efects on the maturation of the receptor.

31 March 2020

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Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome.

31 March 2020

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Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

31 March 2020

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Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

31 March 2020

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Quantitating protein synthesis, degradation, and endogenous antigen processing

31 March 2020

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Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine.

31 March 2020

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A proteasome howdunit: the case of the missing signal

31 March 2020

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Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells

31 March 2020

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Impairment of the ubiquitin-proteasome system by protein aggregation

31 March 2020

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Cellular peptide composition governed by major histocompatibility complex class I molecules.

31 March 2020

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Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody

31 March 2020

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26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate

31 March 2020

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Quantifying recruitment of cytosolic peptides for HLA class I presentation: impact of TAP transport

31 March 2020

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Efficiency of MHC class I antigen processing: a quantitative analysis

31 March 2020

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ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

31 March 2020

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Phagosomes are competent organelles for antigen cross-presentation

31 March 2020

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Direct visualization of distinct T cell epitopes derived from a melanoma tumor-associated antigen by using human recombinant antibodies with MHC- restricted T cell receptor-like specificity.

31 March 2020

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Identification of self peptides bound to purified HLA-B27

31 March 2020

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Tumor antigens and proteomics from the point of view of the major histocompatibility complex peptides

31 March 2020

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Prolyl aminopeptidase from rat brain and kidney. Action on peptides and identification as leucyl aminopeptidase

31 March 2020

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Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase

31 March 2020

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A giant protease with potential to substitute for some functions of the proteasome

31 March 2020

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Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity

31 March 2020

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Tripeptidyl peptidases: enzymes that count

31 March 2020

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Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase

31 March 2020

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Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization

31 March 2020

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Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase

31 March 2020

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Assembly and dissociation of human leukocyte antigen (HLA)-A2 studied by real-time fluorescence resonance energy transfer

31 March 2020

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In vivo newly translated polypeptides are sequestered in a protected folding environment

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1250

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9 August 2017

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