Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins (Q35642280)

9 August 2017

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title

Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins (English)

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9 August 2017

Stefan Duensing

1

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PubMed ID

14750163

9 August 2017

Karl Münger

series ordinal

2

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PubMed ID

14750163

9 August 2017

language of work or name

English

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publication date

1 March 2004

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International Journal of Cancer

9 August 2017

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9 August 2017

109

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9 August 2017

2

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9 August 2017

157-162

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Human papillomavirus immortalization and transformation functions

9 August 2017

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Epidemiologic classification of human papillomavirus types associated with cervical cancer

21 January 2018

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Papillomaviruses and cancer: from basic studies to clinical application

21 January 2018

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Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes

21 January 2018

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The fabric of cancer cell biology-Weaving together the strands

21 January 2018

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Centrosomes, genomic instability, and cervical carcinogenesis

21 January 2018

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Genetic instability and darwinian selection in tumours

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

21 January 2018

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Human papillomavirus oncoproteins alter differentiation-dependent cell cycle exit on suspension in semisolid medium

21 January 2018

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

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Telomerase activation by the E6 gene product of human papillomavirus type 16.

21 January 2018

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Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

21 January 2018

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The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

21 January 2018

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21 January 2018

Centrosomes and cancer

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"It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle

21 January 2018

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

21 January 2018

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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A.

21 January 2018

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

21 January 2018

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Cyclin-dependent kinase control of centrosome duplication

21 January 2018

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21 January 2018

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Centrosome aberrations: cause or consequence of cancer progression?

21 January 2018

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Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes.

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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21 January 2018

Surfing the p53 network

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Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members

21 January 2018

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Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

21 January 2018

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Proliferation of cancer cells despite CDK2 inhibition.

21 January 2018

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Cyclin E ablation in the mouse

21 January 2018

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Calcium, calmodulin, and CaMKII requirement for initiation of centrosome duplication in Xenopus egg extracts

21 January 2018

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Centrosome number is controlled by a centrosome-intrinsic block to reduplication

21 January 2018

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Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes

21 January 2018

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Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

21 January 2018

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Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma

21 January 2018

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The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.

21 January 2018

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

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Specific chromosomal imbalances in human papillomavirus-transfected cells during progression toward immortality

21 January 2018

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HPV-16 oncogenes E6 and E7 are mutagenic in normal human oral keratinocytes

21 January 2018

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Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

21 January 2018

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Low incidence of microsatellite instability in patients with cervical carcinomas.

21 January 2018

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The role of human papillomavirus oncoproteins E6 and E7 in apoptosis

21 January 2018

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Immune evasion in human papillomavirus-associated cervical cancer

21 January 2018

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Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

21 January 2018

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Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells

21 January 2018

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Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

21 January 2018

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Clonality of precursors of cervical cancer and their genetical links to invasive cancer

21 January 2018

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A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques.

21 January 2018

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Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization

21 January 2018

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Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix

21 January 2018

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FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

21 January 2018

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The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

21 January 2018

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FRA3B and other common fragile sites: the weakest links

21 January 2018

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Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles

21 January 2018

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The oncogenic potential of Kaposi's sarcoma-associated herpesvirus cyclin is exposed by p53 loss in vitro and in vivo

21 January 2018

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Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

21 January 2018

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Cell cycle arrest and DNA endoreduplication following p21Waf1/Cip1 expression

21 January 2018

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The human papillomavirus type 16 E6 oncogene induces premature mitotic chromosome segregation

21 January 2018

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Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions

21 January 2018

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Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.11691

1 reference

9 August 2017

1 reference

PubMed ID

14750163