Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint (Q35665702)

9 August 2017

Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint (English)

1 reference

9 August 2017

Alexander P Miceli

1

1 reference

9 August 2017

Anthony J Saporita

series ordinal

2

1 reference

9 August 2017

Jason D Weber

series ordinal

3

1 reference

9 August 2017

language of work or name

English

0 references

publication date

7 November 2011

1 reference

Molecular and Cellular Biology

9 August 2017

1 reference

9 August 2017

32

1 reference

9 August 2017

348-364

1 reference

9 August 2017

2

1 reference

describes a project that uses

9 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3255786/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

mTOR: from growth signal integration to cancer, diabetes and ageing

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Translational regulation of gene expression during conditions of cell stress

27 July 2018

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Tuberous sclerosis complex 1: an epithelial tumor suppressor essential to prevent spontaneous prostate cancer in aged mice

27 July 2018

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5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage

27 July 2018

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Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation

27 July 2018

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Molecular mechanisms of mTOR-mediated translational control

27 July 2018

1 reference

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Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

27 July 2018

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Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability

27 July 2018

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A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function

27 July 2018

1 reference

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Therapeutic targets in the ARF tumor suppressor pathway.

27 July 2018

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Defining the role of mTOR in cancer

27 July 2018

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TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation

27 July 2018

1 reference

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Divorcing ARF and p53: an unsettled case

27 July 2018

1 reference

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

27 July 2018

1 reference

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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

27 July 2018

1 reference

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Dysregulation of the TSC-mTOR pathway in human disease

27 July 2018

1 reference

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Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor

27 July 2018

1 reference

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Cell-cycle checkpoints and cancer

27 July 2018

1 reference

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ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

27 July 2018

1 reference

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Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells.

27 July 2018

1 reference

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

27 July 2018

1 reference

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

27 July 2018

1 reference

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Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

27 July 2018

1 reference

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

27 July 2018

1 reference

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

27 July 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

27 July 2018

1 reference

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Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

27 July 2018

1 reference

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Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis

27 July 2018

1 reference

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Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis

27 July 2018

1 reference

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Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

27 July 2018

1 reference

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Nucleolar Arf sequesters Mdm2 and activates p53

27 July 2018

1 reference

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Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

p14ARF links the tumour suppressors RB and p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

E1A signaling to p53 involves the p19(ARF) tumor suppressor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Cell cycle checkpoints: preventing an identity crisis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Rescue of defective mitogenic signaling by D-type cyclins.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Mechanism of Puromycin Action: Fate of Ribosomes after Release of Nascent Protein Chains from Polysomes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Hallmarks of Cancer: The Next Generation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

New insights into checkpoint kinase 1 in the DNA damage response signaling network

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Developmental strategies for evasion of Arf tumor suppression.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

mTORC1 promotes survival through translational control of Mcl-1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Signalling to translation: how signal transduction pathways control the protein synthetic machinery

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Dmp1 and tumor suppression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

The tuberous sclerosis complex

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Upstream and downstream of mTOR

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

Tumor spectrum in ARF-deficient mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

p19ARF links the tumour suppressor p53 to Ras

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3255786

7 December 2018

Identifiers

DOI

10.1128/MCB.06030-11

1 reference

release_7lhxyp5ievea3cokrdkbvii6ne

9 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7lhxyp5ievea3cokrdkbvii6ne

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3255786

1 reference

9 August 2017

1 reference