RalA functions as an indispensable signal mediator for the nutrient-sensing system (Q35676903)

9 August 2017

title

RalA functions as an indispensable signal mediator for the nutrient-sensing system (English)

1 reference

9 August 2017

Tomohiko Maehama

1

1 reference

9 August 2017

Masahiko Tanaka

2

1 reference

9 August 2017

Hiroshi Nishina

3

1 reference

9 August 2017

Makoto Murakami

4

1 reference

9 August 2017

Yasunori Kanaho

5

1 reference

9 August 2017

Kentaro Hanada

6

1 reference

9 August 2017

language of work or name

English

0 references

publication date

23 October 2008

1 reference

Journal of Biological Chemistry

9 August 2017

number of pages

7

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

9 August 2017

volume

283

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9 August 2017

issue

50

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9 August 2017

page(s)

35053-35059

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

9 August 2017

cites work

1 reference

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12 July 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

12 July 2018

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

12 July 2018

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RalGDS couples growth factor signaling to Akt activation

12 July 2018

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Ral GTPases and cancer: linchpin support of the tumorigenic platform

12 July 2018

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Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

12 July 2018

1 reference

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12 July 2018

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Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

12 July 2018

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Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

12 July 2018

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12 July 2018

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Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformation

12 July 2018

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Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase.

12 July 2018

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12 July 2018

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Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering

12 July 2018

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12 July 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

12 July 2018

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Regulation of the small GTPase Rheb by amino acids.

12 July 2018

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Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

12 July 2018

1 reference

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Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

12 July 2018

1 reference

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Rheb binds and regulates the mTOR kinase

12 July 2018

1 reference

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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

12 July 2018

1 reference

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RalGDS is required for tumor formation in a model of skin carcinogenesis.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Akt regulates growth by directly phosphorylating Tsc2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

The exocyst complex binds the small GTPase RalA to mediate filopodia formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

The small GTPase RalA targets filamin to induce filopodia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Dual requirement for a newly identified phosphorylation site in p70s6k

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Efficient selection for high-expression transfectants with a novel eukaryotic vector

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259907

The exocyst is a Ral effector complex

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18948269

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M805822200

1 reference

9 August 2017

1 reference

9 August 2017

1 reference