Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase (Q36623662)

15 August 2017

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title

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase (English)

1 reference

15 August 2017

Avruch J

1

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15 August 2017

Hara K

2

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15 August 2017

Lin Y

3

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15 August 2017

Liu M

4

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15 August 2017

Long X

5

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15 August 2017

Ortiz-Vega S

6

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15 August 2017

Yonezawa K

7

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

25

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15 August 2017

6361-6372

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15 August 2017

48

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209882

15 August 2017

0 references

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Immunopharmacology of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The Rheb family of GTP-binding proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Recent advances in the regulation of the TOR pathway by insulin and nutrients

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Raf meets Ras: completing the framework of a signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TOR controls translation initiation and early G1 progression in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Mitochondrial signaling: the retrograde response

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Structural and functional analysis of pp70S6k

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Human RAS superfamily proteins and related GTPases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tsc2 is not a critical target of Akt during normal Drosophila development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

FKBP12-Rapamycin-associated Protein or Mammalian Target of Rapamycin (FRAP/mTOR) Localization in the Endoplasmic Reticulum and the Golgi Apparatus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Mechanism of action of the immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The G-protein betagamma complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb binds and regulates the mTOR kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Distinct sites on G protein beta gamma subunits regulate different effector functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Drosophila Rheb GTPase is required for cell cycle progression and cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of the small GTPase Rheb by amino acids.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identification of a conserved motif required for mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The WD repeat: a common architecture for diverse functions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of mTOR and cell growth in response to energy stress by REDD1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Multiple independent inputs are required for activation of the p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Characterization of ubiquilin 1, an mTOR-interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209882

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209882

1 reference

15 August 2017

1 reference