Rap1-Rac1 circuits potentiate platelet activation (Q35683204)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Rap1-Rac1 circuits potentiate platelet activation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1

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16 January 2020

Yacine Boulaftali

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Bertrand Leblond

6

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16 January 2020

author name string

Timothy D Ouellette

3

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16 January 2020

Michael Holinstat

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Laurent Désiré

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Patrick Andre

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Pamela B Conley

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Wolfgang Bergmeier

9

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16 January 2020

publication date

10 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

Arteriosclerosis, Thrombosis, and Vascular Biology

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

32

1 reference

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16 January 2020

issue

2

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16 January 2020

page(s)

434-441

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling

16 January 2020

cites work

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12 July 2018

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Signaling during platelet adhesion and activation

12 July 2018

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The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

12 July 2018

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Rap1, a mercenary among the Ras-like GTPases

12 July 2018

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The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels

12 July 2018

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Specificity in Ras and Rap signaling

12 July 2018

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12 July 2018

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Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway

12 July 2018

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CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets

12 July 2018

1 reference

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Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.

12 July 2018

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Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

12 July 2018

1 reference

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GEFs and GAPs: critical elements in the control of small G proteins

12 July 2018

1 reference

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The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

12 July 2018

1 reference

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Rap1b is required for normal platelet function and hemostasis in mice

12 July 2018

1 reference

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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.

12 July 2018

1 reference

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CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

12 July 2018

1 reference

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

12 July 2018

1 reference

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P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries

12 July 2018

1 reference

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Identification of the platelet ADP receptor targeted by antithrombotic drugs

12 July 2018

1 reference

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Ras and Rho GTPases: a family reunion

12 July 2018

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Rho GTPases and their effector proteins

12 July 2018

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Regulatory and signaling properties of the Vav family

12 July 2018

1 reference

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Role of intracellular signaling events in ADP-induced platelet aggregation.

12 July 2018

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A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

12 July 2018

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

12 July 2018

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

12 July 2018

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

12 July 2018

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Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

12 July 2018

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Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

12 July 2018

1 reference

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CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.

25 September 2018

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Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets.

25 September 2018

1 reference

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Integrin alpha2beta1 induces phosphorylation-dependent and phosphorylation-independent activation of phospholipase Cgamma2 in platelets: role of Src kinase and Rac GTPase.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Rac1 is essential for phospholipase C-gamma2 activation in platelets

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing

25 September 2018

1 reference

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Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.

25 September 2018

1 reference

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Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody

25 September 2018

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Activation of Rap1B by G(i) family members in platelets

25 September 2018

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A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262085

Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets

25 September 2018

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Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.

25 September 2018

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Beta-adrenergic-induced cytosolic redistribution of Rap1 in rat parotid acini: role in secretion.

25 September 2018

1 reference

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Structure and function of rap proteins in human platelets

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22075250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

cAMP is not an important messenger for ADP-induced platelet aggregation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22075250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition and Reversal of Platelet Activation by Cytochalasin B or Colcemid

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22075250

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1161/ATVBAHA.111.239194

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22075250%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference