Insulin signaling defects in type 2 diabetes (Q35711939)

9 August 2017

1 reference

title

Insulin signaling defects in type 2 diabetes (English)

1 reference

9 August 2017

1 reference

1 reference

Juleen R Zierath

3

0 references

author name string

Ying Leng

series ordinal

1

1 reference

PubMed ID

15041786

9 August 2017

Håkan K R Karlsson

series ordinal

2

1 reference

9 August 2017

1 May 2004

1 reference

Reviews in Endocrine and Metabolic Disorders

9 August 2017

1 reference

9 August 2017

5

1 reference

9 August 2017

111-117

1 reference

9 August 2017

2

1 reference

https://scigraph.springernature.com/pub.10.1023/b:remd.0000021432.84588.f6

9 August 2017

0 references

cites work

Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus

1 reference

12 December 2020

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

1 reference

12 December 2020

Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle

1 reference

12 December 2020

Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients

1 reference

12 December 2020

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

12 December 2020

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

1 reference

12 December 2020

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

1 reference

12 December 2020

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

1 reference

12 December 2020

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

12 December 2020

Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus

1 reference

12 December 2020

Insulin signal transduction through protein kinase cascades.

1 reference

12 December 2020

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease

1 reference

12 December 2020

Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects

1 reference

12 December 2020

Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction

1 reference

12 December 2020

Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes

1 reference

12 December 2020

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

12 December 2020

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

1 reference

12 December 2020

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

1 reference

12 December 2020

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

12 December 2020

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

1 reference

12 December 2020

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle

1 reference

12 December 2020

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects.

1 reference

12 December 2020

Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects

1 reference

12 December 2020

Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

1 reference

12 December 2020

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

1 reference

12 December 2020

Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

1 reference

12 December 2020

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

12 December 2020

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

1 reference

12 December 2020

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

1 reference

12 December 2020

Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance

1 reference

12 December 2020

Peroxisome proliferator-activated receptors: insight into multiple cellular functions

1 reference

12 December 2020

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

1 reference

12 December 2020

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

12 December 2020

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

12 December 2020

From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients

1 reference

12 December 2020

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

12 December 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

12 December 2020

Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

1 reference

12 December 2020

Insulin and insulin-like growth factor-1 action on human skeletal muscle: preferential effects of insulin-like growth factor-1 in type 2 diabetic subjects

1 reference

12 December 2020

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

1 reference

12 December 2020

Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action

1 reference

12 December 2020

Insulin action and insulin resistance in human skeletal muscle

1 reference

12 December 2020

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

12 December 2020

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

12 December 2020

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

1 reference

12 December 2020

Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM.

1 reference

12 December 2020

10.1023/B:REMD.0000021432.84588.F6

Identifiers

DOI

1 reference

PubMed ID

15041786

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

15041786