Molecular defects in insulin secretion in type-2 diabetes (Q35711972)

9 August 2017

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title

Molecular defects in insulin secretion in type-2 diabetes (English)

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9 August 2017

2

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9 August 2017

Frances M Ashcroft

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9 August 2017

1 May 2004

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Reviews in Endocrine and Metabolic Disorders

9 August 2017

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9 August 2017

5

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9 August 2017

2

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9 August 2017

135-142

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https://scigraph.springernature.com/pub.10.1023/b:remd.0000021435.87776.a7

9 August 2017

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cites work

Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53).

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12 December 2020

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

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12 December 2020

Glucokinase mutations, insulin secretion, and diabetes mellitus

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12 December 2020

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

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12 December 2020

E23K single nucleotide polymorphism in the islet ATP-sensitive potassium channel gene (Kir6.2) contributes as much to the risk of Type II diabetes in Caucasians as the PPARgamma Pro12Ala variant.

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12 December 2020

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

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12 December 2020

Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials

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12 December 2020

Voltage-dependent K(+) channels in pancreatic beta cells: role, regulation and potential as therapeutic targets

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12 December 2020

Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese

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12 December 2020

Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

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12 December 2020

Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation

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12 December 2020

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12 December 2020

Glucose-sensing in glucagon-like peptide-1-secreting cells

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12 December 2020

Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice

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12 December 2020

Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells associated with impaired glucose responsiveness.

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12 December 2020

Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians

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12 December 2020

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes

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12 December 2020

A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels

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12 December 2020

K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels

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12 December 2020

Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.

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12 December 2020

Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action

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12 December 2020

ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.

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12 December 2020

Temperature and redox state dependence of native Kv2.1 currents in rat pancreatic beta-cells.

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12 December 2020

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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12 December 2020

The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

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12 December 2020

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

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12 December 2020

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes

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12 December 2020

ATP-sensitive K+ channels and insulin secretion: their role in health and disease.

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12 December 2020

Triggering and amplifying pathways of regulation of insulin secretion by glucose

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12 December 2020

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells

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12 December 2020

Mitochondrial function in normal and diabetic beta-cells

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12 December 2020

Clinical and molecular characterization of a dominant form of congenital hyperinsulinism caused by a mutation in the high-affinity sulfonylurea receptor

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12 December 2020

Loss of functional KATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy

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12 December 2020

Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes?

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12 December 2020

Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

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12 December 2020

Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.

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12 December 2020

Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.

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12 December 2020

Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes

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12 December 2020

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

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12 December 2020

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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12 December 2020

A common mitochondrial DNA variant is associated with insulin resistance in adult life.

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12 December 2020

Variations in insulin secretion in carriers of the E23K variant in the KIR6.2 subunit of the ATP-sensitive K(+) channel in the beta-cell

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12 December 2020

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

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12 December 2020

Insulin signalling and the regulation of glucose and lipid metabolism

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12 December 2020

The common single nucleotide polymorphism E23K in K(IR)6.2 sensitizes pancreatic beta-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates

1 reference

12 December 2020

Perchlorate is hypoglycaemic by amplifying glucose-stimulated insulin secretion in mice

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12 December 2020

A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels

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12 December 2020

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

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12 December 2020

Experimental models of transcription factor-associated maturity-onset diabetes of the young

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12 December 2020

Fatty acid metabolism and insulin secretion in pancreatic beta cells

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12 December 2020

Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA

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12 December 2020

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

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12 December 2020

beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors

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12 December 2020

Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose

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12 December 2020

Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians

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12 December 2020

HNF-1alpha G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community

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12 December 2020

Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

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12 December 2020

Diabetes mellitus and genetically programmed defects in beta-cell function

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12 December 2020

Electrophysiology of the pancreatic beta-cell

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12 December 2020

Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

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12 December 2020

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia

1 reference

12 December 2020

Sulphonylurea (Glibenclamide) enhances somatostatin and inhibits glucagon release induced by arginine

1 reference

12 December 2020

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

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12 December 2020

Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes

1 reference

12 December 2020

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets

1 reference

12 December 2020

NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity

1 reference

12 December 2020

Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

1 reference

12 December 2020

Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels

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12 December 2020

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor

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12 December 2020

Non-beta-cell islet abnormalities in noninsulin-dependent diabetes mellitus.

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12 December 2020

10.1023/B:REMD.0000021435.87776.A7

Identifiers

DOI

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PubMed ID

15041789

Dimensions Publication ID

9 August 2017

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1 reference

PubMed ID

15041789