Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity (Q35720003)

25893605

9 August 2017

title

Telomerase regulates MYC-driven oncogenesis independent of its reverse transcriptase activity (English)

1 reference

9 August 2017

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Guido Franzoso

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Cheryl M Koh

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Ekta Khattar

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Shi Chi Leow

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Chia Yi Liu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Wei Xia Ang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Yinghui Li

7

1 reference

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9 June 2020

Shang Li

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Ernesto Guccione

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Vinay Tergaonkar

11

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9 June 2020

language of work or name

English

0 references

publication date

20 April 2015

1 reference

25893605

Journal of Clinical Investigation

9 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

125

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9 June 2020

issue

5

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9 June 2020

page(s)

2109-2122

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

9 June 2020

cites work

1 reference

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Telomerase directly regulates NF-κB-dependent transcription.

27 July 2018

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27 July 2018

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27 July 2018

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Functional genomics identifies therapeutic targets for MYC-driven cancer

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Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

27 July 2018

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Separation of telomerase functions by reverse genetics

27 July 2018

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

27 July 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

27 July 2018

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Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts.

27 July 2018

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Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

27 July 2018

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Proteolytic control of the oncoprotein transcription factor Myc.

27 July 2018

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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

27 July 2018

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Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

27 July 2018

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hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells

27 July 2018

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Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

27 July 2018

1 reference

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p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication

27 July 2018

1 reference

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How telomeres solve the end-protection problem

27 July 2018

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A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

27 July 2018

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HuR recruits let-7/RISC to repress c-Myc expression

27 July 2018

1 reference

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

27 July 2018

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Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

27 July 2018

1 reference

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Analysis of Myc-induced histone modifications on target chromatin

27 July 2018

1 reference

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Model-based analysis of ChIP-Seq (MACS)

27 July 2018

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Mechanisms of MYC stabilization in human malignancies

27 July 2018

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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

27 July 2018

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27 July 2018

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Replication and protection of telomeres

27 July 2018

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The ubiquitin-specific protease USP28 is required for MYC stability

27 July 2018

1 reference

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Soothing the watchman: telomerase reduces the p53-dependent cellular stress response

27 July 2018

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Short telomeres limit tumor progression in vivo by inducing senescence

27 July 2018

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Genetic analysis of myc and telomerase interactions in vivo

27 July 2018

1 reference

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Genes and pathways downstream of telomerase in melanoma metastasis

27 July 2018

1 reference

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Myc-binding-site recognition in the human genome is determined by chromatin context

27 July 2018

1 reference

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

27 July 2018

1 reference

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

27 July 2018

1 reference

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Senescence and immortalization: role of telomeres and telomerase

27 July 2018

1 reference

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Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase extracurricular activities

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Human telomerase and its regulation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

htert expression correlates with MYC over-expression in human prostate cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Direct activation of TERT transcription by c-MYC.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.

27 July 2018

1 reference

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27 July 2018

Myc activates telomerase

1 reference

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Extension of life-span by introduction of telomerase into normal human cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomeres shorten during ageing of human fibroblasts

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Trimmomatic: a flexible trimmer for Illumina sequence data

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase: central regulator of all of the hallmarks of cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Molecular biology. Wnt regulates TERT--putting the horse before the cart.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

DNA damage response: Keeping telomerase at bay.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Telomerase modulates Wnt signalling by association with target gene chromatin

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Switching and signaling at the telomere

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Cell populations during tumorigenesis in Eu-myc transgenic mice.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

Oncogenic activity of the c-Myc protein requires dimerization with Max.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463203

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

25 September 2018

1 reference

12 December 2020

Expression of telomerase inhibits hydroxyl radical-induced apoptosis in normal telomerase negative human lung fibroblasts

1 reference

12 December 2020

Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice

1 reference

12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

12 December 2020

Bcl-2 mediates chemoresistance in matched pairs of primary E(mu)-myc lymphomas in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI79134

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

release_2qmqegys2za55fth5z5zld72k4

9 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2qmqegys2za55fth5z5zld72k4

24 November 2022

mapped directly with Wikidata item

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893605%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

25893605

1 reference