Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins (Q37846533)

24 August 2017

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title

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins (English)

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24 August 2017

María A Blasco

2

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author name string

Paula Martínez

series ordinal

1

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PubMed ID

21346783

24 August 2017

language of work or name

English

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publication date

1 March 2011

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24 August 2017

Nature Reviews Cancer

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24 August 2017

11

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24 August 2017

3

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24 August 2017

161-176

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https://scigraph.springernature.com/pub.10.1038/nrc3025

24 August 2017

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cites work

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

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Switching and signaling at the telomere

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

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Short telomeres limit tumor progression in vivo by inducing senescence

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Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

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Essential role of mouse telomerase in highly proliferative organs

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Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells

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The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression

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Effects of telomerase and telomere length on epidermal stem cell behavior

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Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

31 March 2020

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Telomerase reverse transcriptase delays aging in cancer-resistant mice

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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

31 March 2020

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Telomerase modulates Wnt signalling by association with target gene chromatin

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Conditional telomerase induction causes proliferation of hair follicle stem cells

31 March 2020

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Regulation of telomerase by telomeric proteins

31 March 2020

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Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway

31 March 2020

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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

31 March 2020

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Targeted deletion reveals an essential function for the telomere length regulator Trf1.

31 March 2020

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Telomere protection by TPP1 is mediated by POT1a and POT1b

31 March 2020

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Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication

31 March 2020

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Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

31 March 2020

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Role of shelterin in cancer and aging

31 March 2020

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Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

31 March 2020

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Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis

31 March 2020

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TPP1 is required for TERT recruitment, telomere elongation during nuclear reprogramming, and normal skin development in mice

31 March 2020

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Telomeres and human disease: ageing, cancer and beyond

31 March 2020

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XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer.

31 March 2020

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Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia

31 March 2020

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TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo

31 March 2020

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Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

31 March 2020

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Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

31 March 2020

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Functional interaction between telomere protein TPP1 and telomerase

31 March 2020

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

31 March 2020

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Origin of Concatemeric T7DNA

31 March 2020

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

31 March 2020

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Telomeres shorten during ageing of human fibroblasts

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The longest telomeres: a general signature of adult stem cell compartments

31 March 2020

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Telomere lengthening early in development

31 March 2020

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Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells

31 March 2020

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Cellular senescence in cancer and aging

31 March 2020

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

31 March 2020

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Telomerase mutations in families with idiopathic pulmonary fibrosis

31 March 2020

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A telomerase component is defective in the human disease dyskeratosis congenita

31 March 2020

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Adult-onset pulmonary fibrosis caused by mutations in telomerase

31 March 2020

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

31 March 2020

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Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

31 March 2020

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A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs

31 March 2020

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

31 March 2020

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Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

31 March 2020

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DNA methyltransferases control telomere length and telomere recombination in mammalian cells

31 March 2020

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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

31 March 2020

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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

31 March 2020

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Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

31 March 2020

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How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high-resolution crystal structures

31 March 2020

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TRF1 binds a bipartite telomeric site with extreme spatial flexibility

31 March 2020

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

31 March 2020

1 reference

Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection

31 March 2020

1 reference

Pot1, the putative telomere end-binding protein in fission yeast and humans

31 March 2020

1 reference

POT1 as a terminal transducer of TRF1 telomere length control

31 March 2020

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POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination

31 March 2020

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TIN2 mediates functions of TRF2 at human telomeres

31 March 2020

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

31 March 2020

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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins

31 March 2020

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PTOP interacts with POT1 and regulates its localization to telomeres

31 March 2020

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Telomere maintenance through spatial control of telomeric proteins

31 March 2020

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TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

31 March 2020

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Rap1 affects the length and heterogeneity of human telomeres

31 March 2020

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Identification of human Rap1: implications for telomere evolution

31 March 2020

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Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal

31 March 2020

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Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Genetic instabilities in human cancers

31 March 2020

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Telomeres and telomerase in cancer

31 March 2020

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An oncogene-induced DNA damage model for cancer development

31 March 2020

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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study

31 March 2020

1 reference

Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters.

31 March 2020

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Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma

31 March 2020

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Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis

31 March 2020

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Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia

31 March 2020

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

31 March 2020

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Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

31 March 2020

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Give me a break: how telomeres suppress the DNA damage response

31 March 2020

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The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

31 March 2020

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

31 March 2020

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DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse

31 March 2020

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Telomere loss as a mechanism for chromosome instability in human cancer

31 March 2020

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How telomeres are replicated

31 March 2020

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Physiological relevance of telomeric G-quadruplex formation: a potential drug target

31 March 2020

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In vitro low propensity to form nucleosomes of four telomeric sequences

31 March 2020

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The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres

31 March 2020

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ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

31 March 2020

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Chromosomal instability at common fragile sites in Seckel syndrome

31 March 2020

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

31 March 2020

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Distinct roles of TRF1 in the regulation of telomere structure and lengthening

31 March 2020

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Tpp1/Acd maintains genomic stability through a complex role in telomere protection

31 March 2020

1 reference

Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator

31 March 2020

1 reference

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

31 March 2020

1 reference

TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

31 March 2020

1 reference

Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications

31 March 2020

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Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening

31 March 2020

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Telomeres: hallmarks of radiosensitivity.

31 March 2020

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Accelerated telomere shortening in fibroblasts after extended periods of confluency.

31 March 2020

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Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

31 March 2020

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TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.

31 March 2020

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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

31 March 2020

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Role of the TRF2 telomeric protein in cancer and ageing

31 March 2020

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High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

31 March 2020

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High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

31 March 2020

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31 March 2020

Aneuploidy and cancer

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31 March 2020

Aneuploidy and cancer

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

31 March 2020

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Aneuploidy acts both oncogenically and as a tumor suppressor

31 March 2020

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Persistent telomere damage induces bypass of mitosis and tetraploidy

31 March 2020

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Telomere dysfunction and loss of p53 cooperate in defective mitotic segregation of chromosomes in cancer cells.

31 March 2020

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ATR signaling can drive cells into senescence in the absence of DNA breaks

31 March 2020

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

31 March 2020

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Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

31 March 2020

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Engineered telomere degradation models dyskeratosis congenita

31 March 2020

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Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita

31 March 2020

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Telomerase therapeutics for cancer: challenges and new directions

31 March 2020

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Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements

31 March 2020

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RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

31 March 2020

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A protein-counting mechanism for telomere length regulation in yeast.

31 March 2020

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Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast

31 March 2020

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An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

31 March 2020

2 references

31 March 2020

12 December 2020

Acetylation of the yeast histone H4 N terminus regulates its binding to heterochromatin protein SIR3.

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

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Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae

31 March 2020

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RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.

31 March 2020

1 reference

NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains

31 March 2020

1 reference

Missing pieces in the NF-kappaB puzzle

31 March 2020

1 reference

Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

31 March 2020

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Extension of life-span by introduction of telomerase into normal human cells

31 March 2020

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

31 March 2020

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Cooperation between p53 mutation and high telomerase transgenic expression in spontaneous cancer development

31 March 2020

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Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

31 March 2020

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Genome-wide association study identifies five susceptibility loci for glioma

31 March 2020

1 reference

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

31 March 2020

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Lung cancer susceptibility locus at 5p15.33

31 March 2020

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Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

31 March 2020

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Common 5p15.33 and 6p21.33 variants influence lung cancer risk

31 March 2020

1 reference

Genetic alterations in cervical carcinomas: Frequent low-level amplifications of oncogenes are associated with human papillomavirus infection

31 March 2020

1 reference

Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer

31 March 2020

1 reference

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

31 March 2020

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Short telomeres are sufficient to cause the degenerative defects associated with aging

31 March 2020

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Short telomeres, even in the presence of telomerase, limit tissue renewal capacity

31 March 2020

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Wnt signalling in stem cells and cancer

31 March 2020

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Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours.

31 March 2020

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Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.

31 March 2020

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Actions of human telomerase beyond telomeres

31 March 2020

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Mutations in the RNA component of RNase MRP cause a pleiotropic human disease, cartilage-hair hypoplasia

31 March 2020

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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.

31 March 2020

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Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis

31 March 2020

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Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.

31 March 2020

1 reference

TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability

31 March 2020

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hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.

31 March 2020

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TERT promotes cellular and organismal survival independently of telomerase activity

31 March 2020

1 reference

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

31 March 2020

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No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells

31 March 2020

1 reference

Overexpression analysis of plant transcription factors

31 March 2020

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Transgenic Wnt/TCF pathway reporters: all you need is Lef?

31 March 2020

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Telomerase immunity from bench to bedside: round one.

31 March 2020

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Telomerase and cancer therapeutics

31 March 2020

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The POT1-TPP1 telomere complex is a telomerase processivity factor

31 March 2020

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POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

31 March 2020

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

31 March 2020

1 reference

Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10

31 March 2020

1 reference

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

31 March 2020

1 reference

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia.

31 March 2020

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Evolving views of telomerase and cancer

31 March 2020

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A critical role for telomeres in suppressing and facilitating carcinogenesis

31 March 2020

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A p53-dependent response limits epidermal stem cell functionality and organismal size in mice with short telomeres

31 March 2020

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p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

31 March 2020

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Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse

31 March 2020

1 reference

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

1 reference

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse

31 March 2020

1 reference

Ataxia and pancytopenia caused by a mutation in TINF2

31 March 2020

1 reference

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

31 March 2020

1 reference

Relative contribution of normal and neoplastic cells determines telomerase activity and telomere length in primary cancers of the prostate, colon, and sarcoma.

31 March 2020

1 reference

12 December 2020

The yeast H+-ATPase gene is controlled by the promoter binding factor TUF.

1 reference

12 December 2020

Telomere dysfunction in human diseases: the long and short of it!

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12 December 2020

Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein

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12 December 2020

Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair

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12 December 2020

Breast cancer metastasis: markers and models

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12 December 2020

Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer

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12 December 2020

TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3025

1 reference

release_goq4ogtghrfj7pwxqfhh6voene

24 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/goq4ogtghrfj7pwxqfhh6voene

24 November 2022

mapped directly with Wikidata item

PubMed ID

21346783

1 reference

PubMed ID

21346783