Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling (Q35742331)

10 August 2017

title

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling (English)

1 reference

10 August 2017

0 references

0 references

1 reference

Volker Hovestadt

2

0 references

Martine F Roussel

object named as

Martine F Roussel

12

0 references

Stefan M. Pfister

object named as

Stefan M Pfister

15

0 references

Guido Reifenberger

14

object named as

Guido Reifenberger

1 reference

10 August 2017

16

Peter Lichter

1 reference

10 August 2017

5

Paul A Northcott

1 reference

10 August 2017

13

Andrey Korshunov

1 reference

10 August 2017

8

David T W Jones

1 reference

10 August 2017

11

David Largaespada

1 reference

10 August 2017

10

Branden Moriarity

1 reference

10 August 2017

Marc Zuckermann

1

1 reference

10 August 2017

Christiane B Knobbe-Thomsen

3

1 reference

10 August 2017

Marc Zapatka

4

1 reference

10 August 2017

Kathrin Schramm

6

1 reference

10 August 2017

Jelena Belic

7

1 reference

10 August 2017

Barbara Tschida

9

1 reference

10 August 2017

Daisuke Kawauchi

17

1 reference

10 August 2017

Jan Gronych

18

1 reference

10 August 2017

language of work or name

English

0 references

publication date

11 June 2015

1 reference

10 August 2017

published in

Nature Communications

1 reference

10 August 2017

volume

6

1 reference

10 August 2017

page(s)

7391

1 reference

Creative Commons Attribution 4.0 International

10 August 2017

copyright license

start time

11 June 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4467376/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Cell of origin for malignant gliomas and its implication in therapeutic development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

CRISPR-mediated direct mutation of cancer genes in the mouse liver

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

PEAR: a fast and accurate Illumina Paired-End reAd mergeR.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

The somatic genomic landscape of glioblastoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Lessons from the cancer genome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

RNA-programmed genome editing in human cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

RNA-guided human genome engineering via Cas9

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Multiplex genome engineering using CRISPR/Cas systems

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Medulloblastomics: the end of the beginning

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A restricted cell population propagates glioblastoma growth after chemotherapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Novel mutations target distinct subgroups of medulloblastoma.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A mouse model of the most aggressive subgroup of human medulloblastoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

An animal model of MYC-driven medulloblastoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Molecular subgroups of medulloblastoma: the current consensus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Mouse genomic variation and its effect on phenotypes and gene regulation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Subtypes of medulloblastoma have distinct developmental origins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A rapid and general assay for monitoring endogenous gene modification

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Regulation and mechanisms of mammalian double-strand break repair

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

TM4: a free, open-source system for microarray data management and analysis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Altered neural cell fates and medulloblastoma in mouse patched mutants

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

DNA targeting specificity of RNA-guided Cas9 nucleases

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Spatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Medulloblastoma comprises four distinct molecular variants

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Pleiotropic role for MYCN in medulloblastoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

SeqMap: mapping massive amount of oligonucleotides to the genome

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

In vivo electroporation in the embryonic mouse central nervous system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Stable integration and conditional expression of electroporated transgenes in chicken embryos

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467376

Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS8391

The 2000 World Health Organization classification of tumours of the nervous system

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26067104

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS8391

1 reference

10 August 2017

0 references

1 reference

10 August 2017

1 reference