Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia (Q35779731)

10 August 2017

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title

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia (English)

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10 August 2017

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Motomi Osato

1

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

volume

23

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10 August 2017

issue

24

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10 August 2017

page(s)

4284-4296

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t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

10 August 2017

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Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain

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A novel inherited mutation of the transcription factor RUNX1 causes thrombocytopenia and may predispose to acute myeloid leukaemia

21 January 2018

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Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations

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A novel CBFA2 single-nucleotide mutation in familial platelet disorder with propensity to develop myeloid malignancies.

21 January 2018

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7 January 2021

AML-1 mutations outside the RUNT domain: description of two cases in myeloid malignancies

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

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Absence of point mutations within the AML-1 gene in patients with MDS/AML and loss of chromosome 5q or 7.

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7 January 2021

Inherited platelet-storage pool deficiency associated with a high incidence of acute myeloid leukaemia

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High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

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7 January 2021

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia

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7 January 2021

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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7 January 2021

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

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7 January 2021

Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

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7 January 2021

Lymphoid Enhancer Factor-1 Links Two Hereditary Leukemia Syndromes through Core-binding Factor α Regulation of ELA2

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7 January 2021

Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype

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7 January 2021

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

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7 January 2021

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

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7 January 2021

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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7 January 2021

Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias

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7 January 2021

Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type 1 (NF1) tumour-suppressor gene

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7 January 2021

M0 AML, clinical and biologic features of the disease, including AML1 gene mutations: a report of 59 cases by the Groupe Français d'Hématologie Cellulaire (GFHC) and the Groupe Français de Cytogénétique Hématologique (GFCH)

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7 January 2021

New mechanisms of AML1 gene alteration in hematological malignancies

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7 January 2021

Identification of RUNX1/AML1 as a classical tumor suppressor gene

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7 January 2021

Association of CBFA2 mutation with decreased platelet PKC-θ and impaired receptor-mediated activation of GPIIb-IIIa and pleckstrin phosphorylation: proteins regulated by CBFA2 play a role in GPIIb-IIIa activation

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7 January 2021

Mutation of the AML1/RUNX1 gene in a transient myeloproliferative disorder patient with Down syndrome

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7 January 2021

AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies.

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7 January 2021

C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies

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7 January 2021

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

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7 January 2021

Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype–phenotype correlations

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7 January 2021

CBFA1 Mutation Analysis and Functional Correlation with Phenotypic Variability in Cleidocranial Dysplasia

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207779

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10 August 2017

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