The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion. (Q35801750)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10829078%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion (English)

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7 November 2019

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Acute myeloblastic leukemia

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7

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7 November 2019

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Salomon-Nguyen F

1

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7 November 2019

Della-Valle V

2

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7 November 2019

Mauchauffe M

3

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7 November 2019

Busson-Le Coniat M

4

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7 November 2019

Ghysdael J

5

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7 November 2019

Berger R

6

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7 November 2019

language of work or name

English

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publication date

1 June 2000

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7 November 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 November 2019

volume

97

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7 November 2019

issue

12

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7 November 2019

page(s)

6757-6762

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Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

7 November 2019

cites work

1 reference

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TEL is a sequence-specific transcriptional repressor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Benzene and multiple myeloma: appraisal of the scientific evidence

27 July 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

27 July 2018

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Core-binding factor: a central player in hematopoiesis and leukemia

27 July 2018

1 reference

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The role of TEL fusion genes in pediatric leukemias

27 July 2018

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Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25).

27 July 2018

1 reference

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

27 July 2018

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A unique glucose-dependent apoptotic pathway induced by c-Myc

27 July 2018

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A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma

27 July 2018

1 reference

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

27 July 2018

1 reference

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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

27 July 2018

1 reference

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Environment and cancer: who are susceptible?

27 July 2018

1 reference

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Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia

27 July 2018

1 reference

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Chromosome abnormalities of the short arm of chromosome 12 in hematopoietic malignancies: a report including three novel translocations involving the TEL/ETV6 gene.

27 July 2018

1 reference

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A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

The Ah receptor nuclear translocator gene (ARNT) is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

The novel activation of ABL by fusion to an ets-related gene, TEL.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia.

27 July 2018

1 reference

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Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Oncogenic alterations of metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Analysis of TEL proteins in human leukemias

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Control of cell lineage-specific development and transcription by bHLH-PAS proteins

25 September 2018

1 reference

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The TEL gene products: nuclear phosphoproteins with DNA binding properties

25 September 2018

1 reference

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The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

Deletion of the short arm of chromosome 12 is a secondary event in acute lymphoblastic leukemia with t(12;21)

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18730

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis

15 November 2018

1 reference

12 December 2020

TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

1 reference

12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

12 December 2020

The VHL tumour-suppressor gene paradigm

1 reference

12 December 2020

Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.120162297

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10829078%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10829078%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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