Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. (Q35804427)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213284%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells (English)

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24 December 2019

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3

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24 December 2019

author name string

Lionel A Samayawardhena

series ordinal

1

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24 December 2019

Reuben Kapur

series ordinal

2

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24 December 2019

language of work or name

English

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publication date

9 January 2007

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24 December 2019

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24 December 2019

volume

109

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24 December 2019

issue

9

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24 December 2019

page(s)

3679-3686

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New and emerging roles for mast cells in host defence

24 December 2019

cites work

1 reference

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Signaling pathways influencing SLF and c-kit-mediated survival and proliferation

11 July 2018

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Novel approaches in the treatment of systemic mastocytosis

11 July 2018

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Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell

11 July 2018

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Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge

11 July 2018

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Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways

11 July 2018

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Stem cell factor and its receptor c-Kit as targets for inflammatory diseases

11 July 2018

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Integrated signalling pathways for mast-cell activation

11 July 2018

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Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI

11 July 2018

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Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling

11 July 2018

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Gastrointestinal stromal tumours: an update

11 July 2018

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IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses

11 July 2018

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Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

11 July 2018

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Rho GTPases and the control of cell behaviour

11 July 2018

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Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src.

11 July 2018

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Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor

11 July 2018

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Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

11 July 2018

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Sphingolipids and the balancing of immune cell function: lessons from the mast cell

11 July 2018

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Kit as a human oncogenic tyrosine kinase

11 July 2018

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SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration

11 July 2018

1 reference

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On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

11 July 2018

1 reference

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Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase

11 July 2018

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Do phosphoinositide 3-kinases direct lymphocyte navigation?

11 July 2018

1 reference

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Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

11 July 2018

1 reference

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Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis

11 July 2018

1 reference

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c-Kit-mediated overlapping and unique functional and biochemical outcomes via diverse signaling pathways.

11 July 2018

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Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2

11 July 2018

1 reference

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Role of phosphoinositide 3-kinase signaling in mast cells: new insights from knockout mouse studies.

11 July 2018

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

11 July 2018

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Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions

11 July 2018

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Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells

11 July 2018

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Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells

11 July 2018

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The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization

11 July 2018

1 reference

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Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration

11 July 2018

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SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

11 July 2018

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

11 July 2018

1 reference

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Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy

11 July 2018

1 reference

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Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Demonstration of mast cell chemotactic activity in bronchoalveolar lavage fluid collected from asthmatic patients before and during pollen season

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Demonstration of mast-cell chemotactic activity in nasal lavage fluid: characterization of one chemotaxin as c-kit ligand, stem cell factor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins

11 July 2018

1 reference

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Steel factor and c-kit regulate cell-matrix adhesion.

11 July 2018

1 reference

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rac, a novel ras-related family of proteins that are botulinum toxin substrates

11 July 2018

1 reference

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The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

11 July 2018

1 reference

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Integrins: versatility, modulation, and signaling in cell adhesion

11 July 2018

1 reference

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Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

11 July 2018

1 reference

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The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway

11 July 2018

1 reference

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Integrin-induced tyrosine phosphorylation of protein-tyrosine phosphatase-alpha is required for cytoskeletal reorganization and cell migration

25 September 2018

1 reference

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Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Temporal quantitation of mutant Kit tyrosine kinase signaling attenuated by a novel thiophene kinase inhibitor OSI-930.

25 September 2018

1 reference

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Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

25 September 2018

1 reference

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Versatile retroviral vectors for potential use in gene therapy

25 September 2018

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The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

25 September 2018

1 reference

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Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH 1 responses

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1874564

The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes

15 November 2018

1 reference

12 December 2020

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

1 reference

12 December 2020

Prognostic value of KIT mutation type, mitotic activity, and histologic subtype in gastrointestinal stromal tumors

1 reference

12 December 2020

Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells

1 reference

12 December 2020

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1 reference

12 December 2020

10.1182/BLOOD-2006-11-057315

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213284%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17213284%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

17213284

1 reference