The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). (Q35805056)

10 August 2017

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2). (English)

1 reference

10 August 2017

1 reference

1 reference

Jiri Lukas

2

0 references

author name string

Donato Tedesco

series ordinal

1

1 reference

PMCID

187481

10 August 2017

Steven I Reed

series ordinal

3

1 reference

10 August 2017

1 November 2002

1 reference

10 August 2017

1 reference

10 August 2017

16

1 reference

10 August 2017

22

1 reference

10 August 2017

2946-2957

1 reference

PMCID

187481

describes a project that uses

10 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC187481/fullTextXML

inferred from PubMed Central ID database lookup

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Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

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Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

11 July 2018

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Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor

11 July 2018

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11 July 2018

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Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation

11 July 2018

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Control of retinoblastoma protein-independent hematopoietic cell cycle by the pRB-related p130.

11 July 2018

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11 July 2018

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Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth

11 July 2018

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Proteolysis and the G1-S transition: the SCF connection

11 July 2018

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Regulation of cell proliferation by the E2F transcription factors

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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RB and hbrm cooperate to repress the activation functions of E2F1

11 July 2018

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

11 July 2018

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p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity

11 July 2018

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Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes

11 July 2018

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Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

11 July 2018

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Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation

11 July 2018

1 reference

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The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.

11 July 2018

1 reference

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Retinoblastoma protein family in cell cycle and cancer: a review

11 July 2018

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Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E

11 July 2018

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

11 July 2018

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation

11 July 2018

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Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107.

11 July 2018

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Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

11 July 2018

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An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

11 July 2018

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MyoD induces retinoblastoma gene expression during myogenic differentiation.

11 July 2018

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Principles of CDK regulation

11 July 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

11 July 2018

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The retinoblastoma protein and cell cycle control

11 July 2018

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11 July 2018

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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

11 July 2018

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Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

11 July 2018

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Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

11 July 2018

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Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

11 July 2018

1 reference

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

25 September 2018

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A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

25 September 2018

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The retinoblastoma gene family: cousins with overlapping interests.

25 September 2018

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Role of pRB2/p130 in cellular growth regulation

25 September 2018

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12 December 2020

Immunohistochemical investigation of new suppressor oncogene p130 in oral squamous cell carcinoma

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12 December 2020

Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer

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12 December 2020

Differential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance

1 reference

12 December 2020

A Unique Domain of pRb2/p130 Acts as an Inhibitor of Cdk2 Kinase Activity

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12 December 2020

Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer

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12 December 2020

Toward an understanding of the functional complexity of the E2F and retinoblastoma families

1 reference

12 December 2020

The RB family of cell cycle regulatory factors

1 reference

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

12 December 2020

A CDE/CHR-like element mediates repression of transcription of the mouse RB2 (p130) gene

1 reference

12 December 2020

Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB(-), p16INK4A(+) tumor cells

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12 December 2020

Identifiers

DOI

10.1101/GAD.1011202

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

PMCID

187481