Targeting Syk as a treatment for allergic and autoimmune disorders (Q35814437)

10 August 2017

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title

Targeting Syk as a treatment for allergic and autoimmune disorders (English)

1 reference

10 August 2017

Brian R Wong

1

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10 August 2017

Elliott B Grossbard

series ordinal

2

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10 August 2017

Donald G Payan

series ordinal

3

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10 August 2017

Esteban S Masuda

series ordinal

4

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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Expert Opinion on Investigational Drugs

10 August 2017

published in

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10 August 2017

volume

13

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10 August 2017

issue

7

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10 August 2017

page(s)

743-762

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Structure and function of Syk protein-tyrosine kinase

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Regulation of B cell fates by BCR signaling components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Purification and characterization of human Syk produced using a baculovirus expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

1 reference

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21 January 2018

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21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Molecular adapters in Fc(epsilon)RI signaling and the allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Regulation of mast-cell and basophil function and survival by IgE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cell signal transduction from the high-affinity IgE receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Tyrosine phosphorylation of the linker for activator of T cells in mast cells by stimulation with the high affinity IgE receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Adaptors as central mediators of signal transduction in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cell tumor necrosis factor alpha production is regulated by MEK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Role of activator protein 1, nuclear factor-kappaB, and nuclear factor of activated T cells in IgE receptor-mediated cytokine expression in mature human mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Essential role for Gab2 in the allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

BLNK: a central linker protein in B cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Role of Syk in B-cell development and antigen-receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Syk tyrosine kinase required for mouse viability and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Augmentation of reverse arthus reaction by mast cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Distribution, activation and tryptase/chymase phenotype of mast cells in the rheumatoid lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Cytokine-directed therapies for the treatment of chronic airway diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Activation of human neutrophils by soluble immune complexes: role of Fc gamma RII and Fc gamma RIIIb in stimulation of the respiratory burst and elevation of intracellular Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Syk is required for integrin signaling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Dendritic cells and the control of immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: evidence for a pathogenetic role of B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

CD20: a regulator of cell-cycle progression of B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

B-lymphocyte depletion therapy in rheumatoid arthritis and other autoimmune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Syk regulation of phosphoinositide 3-kinase-dependent NK cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Natural killer cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Multinucleate giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Regulation of the differentiation and function of osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

To make antibodies or not: signaling by the B-cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Akt-dependent cytokine production in mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Immunoreceptor tyrosine-based activation motif-dependent signaling by Kaposi's sarcoma-associated herpesvirus K1 protein: effects on lytic viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Molecular Characterization of the Murine SYK Protein Tyrosine Kinase cDNA, Transcripts and Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Systematic variation in gene expression patterns in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Differentiation state and invasiveness of human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Molecular portraits of human breast tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Quantitative real-time reverse transcription polymerase chain reaction: normalization to rRNA or single housekeeping genes is inappropriate for human tissue biopsies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Mast-cell infiltration of airway smooth muscle in asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The KRN mouse model of inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Transcriptional analysis of targets in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Cutting edge: both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Fcgamma receptor IIa polymorphism in Caucasian patients with systemic lupus erythematosus: association with clinical symptoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Points of control in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Evolving concepts of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Pharmaceutical characteristics that influence the clinical efficacy of inhaled corticosteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Duration of action of inhaled vs. Intravenous beta(2)-adrenoceptor agonists in an anaesthetized guinea-pig model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

Genetic linkage and association of Fc? receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.743

10.1517/13543784.13.7.743

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference