Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease. (Q35819219)

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scientific article published on 22 February 2012

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English	Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease.	scientific article published on 22 February 2012

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23 January 2020

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease (English)

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23 January 2020

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Ana Isabel Rodriguez Perez

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23 January 2020

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Pablo Garrido-Gil

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23 January 2020

Belen Joglar

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23 January 2020

Maria J Guerra

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23 January 2020

Jose L Labandeira-Garcia

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23 January 2020

Journal of Neuroinflammation

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23 January 2020

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23 January 2020

38

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23 January 2020

Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade.

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Peroxisome proliferator-activated receptor alpha activation attenuated angiotensin type 1-mediated but enhanced angiotensin type 2-mediated hemodynamic effects to angiotensin II in the rat.

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Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra.

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Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma

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11 July 2018

An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections

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Molecular activation of PPARgamma by angiotensin II type 1-receptor antagonists

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PPAR-gamma agonists as regulators of microglial activation and brain inflammation.

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Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase

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Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities

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PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin

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Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator

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Protective effect of the inhibition of the renin-angiotensin system on aging

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11 July 2018

PPARgamma, neuroinflammation, and disease

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Angiotensin II, PPAR-gamma and atherosclerosis

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Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS.

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The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

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NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

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The brain renin-angiotensin system: location and physiological roles.

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Peroxisome proliferator-activated receptors in inflammation control

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Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

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PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines

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The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation

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Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: regulation by angiotensin II.

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21 January 2018

The inflammatory response in the MPTP model of Parkinson's disease is mediated by brain angiotensin: relevance to progression of the disease.

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21 January 2018

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS.

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Angiotensin type-1-receptor antagonists reduce 6-hydroxydopamine toxicity for dopaminergic neurons.

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Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity

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21 January 2018

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21 January 2018

Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain.

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NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.

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21 January 2018

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21 January 2018

Role of NAD(P)H oxidase- and mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II.

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21 January 2018

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21 January 2018

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24 September 2018

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24 September 2018

AT1 receptor antagonist telmisartan administered peripherally inhibits central responses to angiotensin II in conscious rats.

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24 September 2018

Role of AT2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR

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Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions

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12 December 2020

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12 December 2020

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Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells

1 reference

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12 December 2020

based on heuristic

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Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22356806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course and morphology of dopaminergic neuronal death caused by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/22356806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22356806

12 December 2020

based on heuristic

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Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/22356806

12 December 2020

based on heuristic

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Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22356806

12 December 2020

based on heuristic

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10.1186/1742-2094-9-38

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23 January 2020

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23 January 2020

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23 January 2020

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