The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications (Q37029352)

17 August 2017

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title

The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications (English)

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17 August 2017

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Qingguang Jiang

1

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17 August 2017

Michael Heneka

series ordinal

2

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17 August 2017

Gary E Landreth

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3

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17 August 2017

language of work or name

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1 January 2008

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17 August 2017

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17 August 2017

22

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17 August 2017

1

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17 August 2017

1-14

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https://scigraph.springernature.com/pub.10.2165/00023210-200822010-00001

17 August 2017

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Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

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12 December 2020

Transcriptional control of adipogenesis

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12 December 2020

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein

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12 December 2020

Inflammation, apoptosis, and Alzheimer's disease

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12 December 2020

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

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12 December 2020

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12 December 2020

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12 December 2020

Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease.

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12 December 2020

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12 December 2020

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

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12 December 2020

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12 December 2020

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

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12 December 2020

Inflammation and Alzheimer's disease pathogenesis

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12 December 2020

Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models

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12 December 2020

Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling.

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12 December 2020

Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

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12 December 2020

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

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12 December 2020

Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression.

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12 December 2020

Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes

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12 December 2020

Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

1 reference

12 December 2020

New pharmacological perspectives and therapeutic potential of PPAR-gamma agonists

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12 December 2020

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

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12 December 2020

Rosiglitazone induces mitochondrial biogenesis in mouse brain.

1 reference

12 December 2020

The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

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12 December 2020

Inflammation: the link between insulin resistance, obesity and diabetes

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12 December 2020

Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.

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12 December 2020

Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

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12 December 2020

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

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12 December 2020

Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures.

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12 December 2020

Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

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12 December 2020

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

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12 December 2020

Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes

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12 December 2020

Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease

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12 December 2020

Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

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12 December 2020

Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.

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12 December 2020

Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene

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12 December 2020

Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis.

1 reference

12 December 2020

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

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12 December 2020

PPAR(gamma) and glucose homeostasis

1 reference

12 December 2020

The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

1 reference

12 December 2020

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

1 reference

12 December 2020

Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials

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12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

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12 December 2020

Altered PPARgamma expression and activation after transient focal ischemia in rats.

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12 December 2020

Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease.

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12 December 2020

Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

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12 December 2020

Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse

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12 December 2020

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

1 reference

12 December 2020

The role of insulin, insulin growth factor, and insulin-degrading enzyme in brain aging and Alzheimer's disease

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300.

1 reference

12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

12 December 2020

Genetic models for CNS inflammation

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12 December 2020

Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

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12 December 2020

The coregulator exchange in transcriptional functions of nuclear receptors

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12 December 2020

Lack of specific amyloid-beta(1-42) suppression by nonsteroidal anti-inflammatory drugs in young, plaque-free Tg2576 mice and in guinea pig neuronal cultures

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12 December 2020

Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures.

1 reference

12 December 2020

Liver X receptors as integrators of metabolic and inflammatory signaling

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12 December 2020

A perspective on inflammation in Alzheimer's disease.

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12 December 2020

Inflammation and the degenerative diseases of aging

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12 December 2020

Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B

1 reference

12 December 2020

The mechanisms of action of PPARs

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12 December 2020

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

12 December 2020

Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes

1 reference

12 December 2020

Cholesterol and the biology of Alzheimer's disease.

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12 December 2020

Disposition of the new antidiabetic agent pioglitazone in rats, dogs, and monkeys

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12 December 2020

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Pioglitazone: a review of its use in type 2 diabetes mellitus

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12 December 2020

10.2165/00023210-200822010-00001

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DOI

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Dimensions Publication ID

17 August 2017

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