The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. (Q35828032)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

review article

1 reference

title

The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

author name string

Sharon Miksys

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

language of work or name

English

0 references

publication date

1 May 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

published in

Drug Metabolism Reviews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

volume

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

page(s)

313-333

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

Rat brain cytochromes P-450: catalytic, immunochemical properties and inducibility of multiple forms

30 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The chronic administration of nicotine induces cytochrome P450 in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Differential effect of chronic nicotine administration on brain cytochrome P4501A1/2 and P4502E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The effects of nicotine on neural pathways implicated in depression: a factor in nicotine addiction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Multiple forms of cytochrome P450 and associated monooxygenase activities in human brain mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Purification of multiple forms of cytochrome P450 from a human brain and reconstitution of catalytic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Precipitated withdrawal following codeine administration is dependent on CYP genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Constitutive expression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The role of CYP2B6 in human xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Chronic ethanol consumption: from neuroadaptation to neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Dopamine formation from tyramine by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Progesterone oxidation by cytochrome P450 2D isoforms in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The role of pharmacogenetically-variable cytochrome P450 enzymes in drug abuse and dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Polymorphism of cytochrome P450 and xenobiotic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Metabolism of (-)-(S)-nicotine by guinea pig and rat brain: identification of cotinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Functional characterization of cytochrome P450 2B6 allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Inhibition of cytochrome P450 2D6 modifies codeine abuse liability

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochrome P450 in rat astrocytes in vivo and in vitro: intracellular localization and induction by phenytoin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Bupropion and 4-OH-bupropion pharmacokinetics in relation to genetic polymorphisms in CYP2B6

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochrome P450 2D Catalyze Steroid 21-Hydroxylation in the Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Enzymatic and chemical demethylenation of (methylenedioxy)amphetamine and (methylenedioxy)methamphetamine by rat brain microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Regional distribution of individual forms of cytochrome P450 mRNA in normal adult human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The route and significance of endogenous synthesis of alkaloids in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The genetic polymorphism of debrisoquine/sparteine metabolism-molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Regional and cellular distribution of CYP2D subfamily members in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

In situ hybridization and immunohistochemical analysis of cytochrome P450 1B1 expression in human normal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The role of metabolism in determining susceptibility to parathion toxicity in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Enzyme-specific transport of rat liver cytochrome P450 to the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Inhibition of cytochrome P450 2E1 induces an increase in extracellular dopamine in rat substantia nigra: a new metabolic pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Involvement of human liver cytochrome P4502B6 in the metabolism of propofol

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Tardive dyskinesia and debrisoquine 4-hydroxylase (CYP2D6) genotype in Japanese schizophrenics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Prevalence of smoking in psychiatric patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Review of bupropion for smoking cessation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

P450 enzymes and Parkinson's disease: the story so far.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Morphological Alterations in Hippocampus After Long-Term Alcohol Consumption in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

CYP2D6 ultrarapid metabolizer genotype as a potential modifier of smoking behaviour.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Induction of CYP2B1/2 and nicotine metabolism by ethanol in rat liver but not rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Induction of nicotine-metabolizing CYP2B1 by ethanol and ethanol-metabolizing CYP2E1 by nicotine: summary and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochromes P450 in brain: function and significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Association of CYP2D microsatellite polymorphism with Lewy body variant of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The prevalence of alcoholic cerebellar atrophy. A morphometric and histological study of an autopsy material.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Environmental tobacco smoke and the risk of cancer in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Genetics of alcohol and tobacco use in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Effect of ethanol on cytochrome P450 in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochrome P450 in the breast and brain: role in tissue-specific activation of xenobiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Quantitation of cytochrome P450 mRNA levels in human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Distribution and kinetics of ethanol metabolism in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Relationship between personality and debrisoquine hydroxylation capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Dextromethorphan O-demethylase activity in rat brain microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120034149

21 January 2018

Identifiers

DOI

10.1081/DMR-120034149

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15237857%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference