DNA damage checkpoint kinase Chk2 triggers replicative senescence (Q35835972)

10 August 2017

DNA damage checkpoint kinase Chk2 triggers replicative senescence (English)

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10 August 2017

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Véronique Gire

1

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10 August 2017

Pierre Roux

2

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10 August 2017

David Wynford-Thomas

3

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10 August 2017

Jean-Marc Brondello

4

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10 August 2017

Vjekoslav Dulic

5

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10 August 2017

language of work or name

English

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publication date

10 June 2004

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10 August 2017

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10 August 2017

23

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10 August 2017

13

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10 August 2017

2554-2563

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describes a project that uses

10 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC449769/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

1 reference

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A DNA damage checkpoint response in telomere-initiated senescence

11 July 2018

1 reference

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DNA damage foci at dysfunctional telomeres

11 July 2018

1 reference

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POT1 as a terminal transducer of TRF1 telomere length control

11 July 2018

1 reference

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Telomere attrition and Chk2 activation in human heart failure

11 July 2018

1 reference

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Short telomeres induce a DNA damage response in Saccharomyces cerevisiae

11 July 2018

1 reference

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Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage

11 July 2018

1 reference

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

11 July 2018

1 reference

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Chk2 activation and phosphorylation-dependent oligomerization

11 July 2018

1 reference

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Senescence Induced by Altered Telomere State, Not Telomere Loss

11 July 2018

1 reference

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Protection of mammalian telomeres

11 July 2018

1 reference

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Immortalisation and transformation revisited

11 July 2018

1 reference

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CHK2 kinase--a busy messenger.

11 July 2018

1 reference

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

11 July 2018

1 reference

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

11 July 2018

1 reference

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

11 July 2018

1 reference

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

11 July 2018

1 reference

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

11 July 2018

1 reference

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

11 July 2018

1 reference

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Mammalian telomeres end in a large duplex loop

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Essential role of mouse telomerase in highly proliferative organs

11 July 2018

1 reference

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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

TRF2 Protects Human Telomeres from End-to-End Fusions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Extension of life-span by introduction of telomerase into normal human cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Telomeres shorten during ageing of human fibroblasts

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Extensive allelic variation and ultrashort telomeres in senescent human cells.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=449769

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

24 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600259

Plasma antioxidants from chocolate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600259

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600259

Initial steps of ferulic acid polymerization by lignin peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600259

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7600259

Erosion of the telomeric single-strand overhang at replicative senescence

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15192702

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7600259

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

15192702

1 reference