Pathways of apoptotic and non-apoptotic death in tumour cells (Q35852309)

10 August 2017

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title

Pathways of apoptotic and non-apoptotic death in tumour cells (English)

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10 August 2017

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Hitoshi Okada

1

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PubMed ID

15286739

10 August 2017

Tak W Mak

series ordinal

2

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PubMed ID

15286739

10 August 2017

language of work or name

English

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publication date

1 August 2004

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10 August 2017

Nature Reviews Cancer

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10 August 2017

4

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10 August 2017

592-603

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10 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc1412

10 August 2017

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The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

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The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

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Endonuclease G is an apoptotic DNase when released from mitochondria

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

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HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

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The serial cultivation of human diploid cell strains

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

31 March 2020

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

31 March 2020

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Role of the INK4a locus in tumor suppression and cell mortality.

31 March 2020

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

31 March 2020

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

31 March 2020

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Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

31 March 2020

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Reducing mammary cancer risk through premature stem cell senescence.

31 March 2020

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Regulation of the apoptosis-necrosis switch

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Vacuolar import of proteins and organelles from the cytoplasm

31 March 2020

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Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

31 March 2020

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Do all programmed cell deaths occur via apoptosis?

31 March 2020

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Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

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The TOR kinases link nutrient sensing to cell growth

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Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

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Autophagy genes are essential for dauer development and life-span extension in C. elegans

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Autophagic programmed cell death in Drosophila

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Disappearance of Rohon-Beard neurons from the spinal cord of larval Xenopus laevis

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Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases

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Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

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X-linked myopathy with excessive autophagy: a new hereditary muscle disease

31 March 2020

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

31 March 2020

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cdc25+ functions as an inducer in the mitotic control of fission yeast.

31 March 2020

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Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle

31 March 2020

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Phosphorylation and activation of 13S condensin by Cdc2 in vitro

31 March 2020

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Nuclear envelope: torn apart at mitosis

31 March 2020

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The mitotic spindle: a self-made machine

31 March 2020

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CDK Inactivation Is the Only Essential Function of the APC/C and the Mitotic Exit Network Proteins for Origin Resetting during Mitosis

31 March 2020

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Cell cycle checkpoint signaling through the ATM and ATR kinases

31 March 2020

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

31 March 2020

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

31 March 2020

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Cdc25C interacts with PCNA at G2/M transition

31 March 2020

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

31 March 2020

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Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation

31 March 2020

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

31 March 2020

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Genomic instability in mice lacking histone H2AX

31 March 2020

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

31 March 2020

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

31 March 2020

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53BP1, a mediator of the DNA damage checkpoint

31 March 2020

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

31 March 2020

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

31 March 2020

1 reference

MDC1 is a mediator of the mammalian DNA damage checkpoint

31 March 2020

1 reference

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

31 March 2020

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MDC1 is required for the intra-S-phase DNA damage checkpoint

31 March 2020

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Drosophila checkpoint kinase 2 couples centrosome function and spindle assembly to genomic integrity

31 March 2020

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Aberrations of cell cycle and cell death in normal development of the chick embryo growth plate

31 March 2020

1 reference

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

31 March 2020

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Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

31 March 2020

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Survivin is required for stable checkpoint activation in taxol-treated HeLa cells

31 March 2020

1 reference

31 March 2020

Oncogenes and cell death

1 reference

A matter of life and cell death

31 March 2020

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

31 March 2020

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Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation

31 March 2020

1 reference

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 March 2020

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

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p53, the cellular gatekeeper for growth and division

31 March 2020

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31 March 2020

Surfing the p53 network

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

31 March 2020

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Live or let die: the cell's response to p53

31 March 2020

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

31 March 2020

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p53 is required for radiation-induced apoptosis in mouse thymocytes

31 March 2020

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Adenovirus E1A oncogene expression in tumor cells enhances killing by TNF-related apoptosis-inducing ligand (TRAIL).

31 March 2020

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

31 March 2020

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Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

31 March 2020

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Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

31 March 2020

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Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis

31 March 2020

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Fas ligand-induced apoptosis

31 March 2020

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Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer.

31 March 2020

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Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

1 reference

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

31 March 2020

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Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

31 March 2020

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Modulation of cellular apoptotic potential: contributions to oncogenesis

31 March 2020

1 reference

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

31 March 2020

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

31 March 2020

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beta-catenin is a target for the ubiquitin-proteasome pathway

31 March 2020

1 reference

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

31 March 2020

1 reference

The Hedgehog and Wnt signalling pathways in cancer

31 March 2020

1 reference

Regulation of p53 stability by Mdm2

31 March 2020

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Mdm2 promotes the rapid degradation of p53

31 March 2020

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

31 March 2020

1 reference

The MDM2 gene amplification database

31 March 2020

1 reference

Molecular basis of the VHL hereditary cancer syndrome

31 March 2020

1 reference

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

31 March 2020

1 reference

Akt protein kinase inhibits non-apoptotic programmed cell death induced by ceramide

31 March 2020

1 reference

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

31 March 2020

1 reference

c-myc induces autophagy in rat 3Y1 fibroblast cells.

31 March 2020

1 reference

Autophagosome formation in mammalian cells

31 March 2020

1 reference

Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.

31 March 2020

1 reference

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

31 March 2020

1 reference

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

31 March 2020

1 reference

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

31 March 2020

1 reference

Mitotic kinases as regulators of cell division and its checkpoints

31 March 2020

1 reference

Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells

31 March 2020

1 reference

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

31 March 2020

1 reference

Assignment of STK6 to human chromosome 20q13.2-->q13.3 and a pseudogene STK6P to 1q41-->q42

31 March 2020

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

31 March 2020

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

31 March 2020

1 reference

Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis

31 March 2020

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Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

31 March 2020

1 reference

bcl-2 over-expression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells

31 March 2020

1 reference

Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following gamma-irradiation

31 March 2020

1 reference

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

31 March 2020

1 reference

Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

31 March 2020

1 reference

Chromosomal passengers and the (aurora) ABCs of mitosis

31 March 2020

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Survivin, versatile modulation of cell division and apoptosis in cancer

31 March 2020

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Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

31 March 2020

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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin

31 March 2020

1 reference

HBXIP functions as a cofactor of survivin in apoptosis suppression

31 March 2020

1 reference

Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis.

31 March 2020

1 reference

The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone

31 March 2020

1 reference

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

31 March 2020

1 reference

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

31 March 2020

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Control of apoptosis and mitotic spindle checkpoint by survivin

31 March 2020

1 reference

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

31 March 2020

1 reference

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.

31 March 2020

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

31 March 2020

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Abnormal centrosome amplification in the absence of p53.

31 March 2020

1 reference

Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function

31 March 2020

1 reference

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRC1412

1 reference

10 August 2017

1 reference

PubMed ID

15286739