Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds (Q35859850)

10 August 2017

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title

Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds (English)

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10 August 2017

Pierre A Coulombe

1

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PubMed ID

15303099

10 August 2017

Pauline Wong

series ordinal

2

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10 August 2017

1 August 2004

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10 August 2017

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10 August 2017

6

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10 August 2017

8

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10 August 2017

699-706

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https://scigraph.springernature.com/pub.10.1038/ncb0804-699

10 August 2017

0 references

cites work

Intermediate filaments as mechanical integrators of cellular space

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7 January 2021

Characterization of the Hydra lamin and its gene: A molecular phylogeny of metazoan lamins.

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7 January 2021

Lamins: building blocks or regulators of gene expression?

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7 January 2021

The nuclear lamina and its functions in the nucleus

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7 January 2021

Intermediate filaments: structure, dynamics, function, and disease

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7 January 2021

A structural scaffolding of intermediate filaments in health and disease

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7 January 2021

Molecular architecture of intermediate filaments

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7 January 2021

Functional complexity of intermediate filament cytoskeletons: from structure to assembly to gene ablation

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7 January 2021

The intermediate filament architecture as determined by X-ray diffraction modeling of hard alpha-keratin.

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Identification of novel principles of keratin filament network turnover in living cells

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The strange case of the "lumper" lamin A/C gene and human premature ageing

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

How do mutations in lamins A and C cause disease?

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Proteins that bind A-type lamins: integrating isolated clues

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The 'ins' and 'outs' of intermediate filament organization.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Are desmosomes more than tethers for intermediate filaments?

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Bridging cytoskeletal intersections.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Plakins: a family of versatile cytolinker proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The 'spectraplakins': cytoskeletal giants with characteristics of both spectrin and plakin families

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The laminopathies: nuclear structure meets disease

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Molecular phylogeny of metazoan intermediate filament proteins.

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The bacterial cytoskeleton: an intermediate filament-like function in cell shape

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Prokaryotic origin of the actin cytoskeleton

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Crystal structure of the bacterial cell-division protein FtsZ

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Functions of intermediate filaments in neuronal development and disease

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Intermediate filament formation by a yeast protein essential for organelle inheritance.

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https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratins: guardians of the liver.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Apoptosis and keratin intermediate filaments

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Beyond structure: do intermediate filaments modulate cell signalling?

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The quest for the function of simple epithelial keratins

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Mid-gestational lethality in mice lacking keratin 8

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin 8 mutations in patients with cryptogenic liver disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin 8 protection of placental barrier function

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin 17 null mice exhibit age- and strain-dependent alopecia

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The secret life of the hair follicle

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratins modulate colonocyte electrolyte transport via protein mistargeting

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Cdk5 regulates the organization of Nestin and its association with p35

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

DEDD regulates degradation of intermediate filaments during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Intermediate filaments control the intracellular distribution of caspases during apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Lamin proteolysis facilitates nuclear events during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Partial cleavage of A-type lamins concurs with their total disintegration from the nuclear lamina during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Caspase proteolysis of desmin produces a dominant-negative inhibitor of intermediate filaments and promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Apoptosis generates stable fragments of human type I keratins

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Measurement of an apoptotic product in the sera of breast cancer patients

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Intermediate filament dynamics

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Dynamic organisation of intermediate filaments and associated proteins during the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Modulation of cell proliferation by cytokeratins K10 and K16

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Sequential expression of mRNA-encoded keratin sets in neonatal mouse epidermis: Basal cells with properties of terminally differentiating cells

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

The 14-3-3 cancer connection

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Wound healing--aiming for perfect skin regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Human wound repair. I. Epidermal regeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Changes in keratinocyte maturation during wound healing

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

p120 Catenin is required for growth factor-dependent cell motility and scattering in epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Role for keratins 6 and 17 during wound closure in embryonic mouse skin

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Generation and characterization of epidermolysis bullosa simplex cell lines: scratch assays show faster migration with disruptive keratin mutations.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Viscoelastic properties of vimentin compared with other filamentous biopolymer networks

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

A 'hot-spot' mutation alters the mechanical properties of keratin filament networks

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Vimentin is secreted by activated macrophages

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function.

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Effects of desmin gene knockout on mice heart mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density

1 reference

https://api.crossref.org/works/10.1038%2FNCB0804-699

7 January 2021

Identifiers

DOI

10.1038/NCB0804-699

1 reference

10 August 2017

1 reference

PubMed ID

15303099