Apoptosome formation and caspase activation: is it different in the heart? (Q35879493)

10 August 2017

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title

Apoptosome formation and caspase activation: is it different in the heart? (English)

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10 August 2017

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Lech Czerski

1

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PubMed ID

15350837

10 August 2017

Gabriel Nuñez

series ordinal

2

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10 August 2017

1 September 2004

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Journal of Molecular and Cellular Cardiology

10 August 2017

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10 August 2017

37

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10 August 2017

643-652

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10 August 2017

3

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PROGRAMMED CELL DEATH--I. CYTOLOGY OF DEGENERATION IN THE INTERSEGMENTAL MUSCLES OF THE PERNYI SILKMOTH.

10 August 2017

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

7 January 2021

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Cell death: the significance of apoptosis

7 January 2021

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7 January 2021

Mechanisms of cell death

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Toward an understanding of the molecular mechanisms of physiological cell death.

7 January 2021

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Genetic control of programmed cell death in the nematode C. elegans.

7 January 2021

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cell death: critical control points

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspases: the executioners of apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase structure, proteolytic substrates, and function during apoptotic cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

A unified model for apical caspase activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structural basis for the activation of human procaspase-7

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mechanisms of caspase activation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase-9 can be activated without proteolytic processing

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mechanisms of caspase activation and inhibition during apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis by death factor

7 January 2021

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Death receptors: signaling and modulation

7 January 2021

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TNF-R1 signaling: a beautiful pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Pro-caspase-3 is a major physiologic target of caspase-8.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase 8: igniting the death machine

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Requirement of cooperative functions of two repeated death effector domains in caspase-8 and in MC159 for induction and inhibition of apoptosis, respectively

7 January 2021

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An induced proximity model for caspase-8 activation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Interdimer processing mechanism of procaspase-8 activation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Multiple conformations of physiological membrane-bound cytochrome c

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cytochrome c release from mitochondria proceeds by a two-step process

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Breaking the mitochondrial barrier

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mitochondrial membrane permeabilization during the apoptotic process

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structure of Bax: coregulation of dimer formation and intracellular localization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

The NOD: a signaling module that regulates apoptosis and host defense against pathogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

NODs: intracellular proteins involved in inflammation and apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

The Apaf-1 apoptosome: a large caspase-activating complex

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase-9 and APAF-1 form an active holoenzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Negative regulation of the Apaf-1 apoptosome by Hsp70

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

IAP proteins: blocking the road to death's door

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

IAP family proteins--suppressors of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structural basis for the inhibition of caspase-3 by XIAP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structural basis of caspase-7 inhibition by XIAP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mechanism of XIAP-mediated inhibition of caspase-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structural basis of IAP recognition by Smac/DIABLO

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptotic pathway activation from mitochondria and death receptors without caspase-3 cleavage in failing human myocardium: fragile balance of myocyte survival?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

BH3-Only proteins-essential initiators of apoptotic cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mitochondria, AIF and caspases--rivaling for cell death execution.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Endonuclease G is an apoptotic DNase when released from mitochondria

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Movement of Bax from the cytosol to mitochondria during apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

A matter of life and death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Regulation of apoptosis by endoplasmic reticulum pathways.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Human caspase 12 has acquired deleterious mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis in myocardial infarction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

New insights into the role of apoptosis in cardiovascular disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Mitochondria in apoptosis of ischemic heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Regulation of cardiac myocyte cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Intracellular ATP is required for mitochondrial apoptotic pathways in isolated hypoxic rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis in human acute myocardial infarction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis is initiated by myocardial ischemia and executed during reperfusion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Blocking caspase-activated apoptosis improves contractility in failing myocardium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis in heart failure: is there light at the end of the tunnel (TUNEL)?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

A mechanistic role for cardiac myocyte apoptosis in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Inhibition of death receptor signals by cellular FLIP

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase activation and mitochondrial cytochrome C release during hypoxia-mediated apoptosis of adult ventricular myocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Apoptosis and Post-infarction Left Ventricular Remodeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Caspase inhibition and limitation of myocardial infarct size: protection against lethal reperfusion injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

ARC inhibits cytochrome c release from mitochondria and protects against hypoxia-induced apoptosis in heart-derived H9c2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

The apoptotic regulatory protein ARC (apoptosis repressor with caspase recruitment domain) prevents oxidant stress-mediated cell death by preserving mitochondrial function

7 January 2021

1 reference

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Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

TAT protein transduction into isolated perfused hearts: TAT-apoptosis repressor with caspase recruitment domain is cardioprotective

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

Blocking the development of postischemic cardiomyopathy with viral gene transfer of the apoptosis repressor with caspase recruitment domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2004.04.016

10.1016/J.YJMCC.2004.04.016

7 January 2021

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15350837