Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain (Q35889023)

10 August 2017

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain (English)

1 reference

10 August 2017

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1 reference

Weizhe Hong

3

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author name string

Margaret M P Pearce

1

1 reference

10 August 2017

Ellen J Spartz

2

1 reference

10 August 2017

Liqun Luo

4

1 reference

10 August 2017

Ron R Kopito

5

1 reference

10 August 2017

language of work or name

English

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publication date

13 April 2015

1 reference

10 August 2017

Nature Communications

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10 August 2017

6

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10 August 2017

6768

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describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4515032/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Proteostasis impairment in protein-misfolding and -aggregation diseases

11 July 2018

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The amyloid state and its association with protein misfolding diseases.

11 July 2018

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Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

11 July 2018

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Microglial phagocytosis of live neurons

11 July 2018

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Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

11 July 2018

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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

11 July 2018

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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

11 July 2018

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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

11 July 2018

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Reactive gliosis and the multicellular response to CNS damage and disease.

11 July 2018

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Microglial dysfunction in brain aging and Alzheimer's disease

11 July 2018

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Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila

11 July 2018

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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

11 July 2018

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Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

11 July 2018

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Biology and genetics of prions causing neurodegeneration

11 July 2018

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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

11 July 2018

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

11 July 2018

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Prion-like properties of pathological TDP-43 aggregates from diseased brains

11 July 2018

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

11 July 2018

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

11 July 2018

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The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function

11 July 2018

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

11 July 2018

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TREM2 Variants in Alzheimer's Disease

11 July 2018

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

11 July 2018

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Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

11 July 2018

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Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

11 July 2018

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Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

11 July 2018

1 reference

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Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation

11 July 2018

1 reference

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Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface

11 July 2018

1 reference

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Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy

11 July 2018

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A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture

11 July 2018

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Intercellular (mis)communication in neurodegenerative disease.

11 July 2018

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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

11 July 2018

1 reference

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Propagation of tau pathology in a model of early Alzheimer's disease

11 July 2018

1 reference

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Trans-synaptic spread of tau pathology in vivo

11 July 2018

1 reference

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The cell biology of receptor-mediated virus entry

11 July 2018

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Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

11 July 2018

1 reference

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Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

11 July 2018

1 reference

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Huntington's disease: from molecular pathogenesis to clinical treatment

11 July 2018

1 reference

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The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Life on the inside: the intracellular lifestyle of cytosolic bacteria

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Propagation of tau misfolding from the outside to the inside of a cell.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

AccPbFRET: an ImageJ plugin for semi-automatic, fully corrected analysis of acceptor photobleaching FRET images

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Engulfment of apoptotic cells: signals for a good meal

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Onset and progression in inherited ALS determined by motor neurons and microglia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Stages in the development of Parkinson's disease-related pathology

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Neuropathological stageing of Alzheimer-related changes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Mutant huntingtin is present in neuronal grafts in Huntington disease patients

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Wlds protection distinguishes axon degeneration following injury from naturally occurring developmental pruning

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Molecular, anatomical, and functional organization of the Drosophila olfactory system.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4515032

24 September 2018

Identifiers

DOI

10.1038/NCOMMS7768

1 reference

Dimensions Publication ID

10 August 2017

0 references

0 references

1 reference

10 August 2017

PubMed publication ID

25866135

1 reference