Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease (Q36958185)

17 August 2017

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title

Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease (English)

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17 August 2017

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Hindupur K Anandatheerthavarada

series ordinal

1

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PubMed ID

17911214

17 August 2017

Latha Devi

series ordinal

2

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17 August 2017

2 October 2007

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17 August 2017

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17 August 2017

13

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17 August 2017

6

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17 August 2017

626-638

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Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

17 August 2017

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Targeting of NH2-terminal-processed microsomal protein to mitochondria: a novel pathway for the biogenesis of hepatic mitochondrial P450MT2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Dual targeting of cytochrome P4502B1 to endoplasmic reticulum and mitochondria involves a novel signal activation by cyclic AMP-dependent phosphorylation at ser128.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Localization of amyloid beta protein messenger RNA in brains from patients with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondrial dysfunction in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondria take center stage in aging and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Emerging functions of mammalian mitochondrial fusion and fission

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-beta1-42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Cognitive and behavioral heterogeneity in Alzheimer's disease: seeking the neurobiological basis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

A postmortem study of amino acid neurotransmitters in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Multiple mechanisms underlie neurotoxicity by different types of Alzheimer's disease mutations of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Monoamine neurotransmitters and their metabolites in brain regions in Alzheimer's disease: a postmortem study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mitochondria and neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Cytochrome oxidase deficiency in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Protein kinase A-mediated phosphorylation modulates cytochrome c oxidase function and augments hypoxia and myocardial ischemia-related injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

The mitochondrial import machinery for preproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Human Cortical Neuronal Cell Line: Establishment From a Patient with Unilateral Megalencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Translating cell biology into therapeutic advances in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Expression of amyloid precursor protein in human astrocytes in vitro: isoform-specific increases following heat shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Characterization of the human heart mitochondrial proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

The role of presenilins in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

Ultrastructural localization of Alzheimer amyloid beta/A4 protein precursor in the cytoplasm of neurons and senile plaque-associated astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858407303536

21 January 2018

Identifiers

DOI

10.1177/1073858407303536

1 reference

17 August 2017

1 reference

PubMed ID

17911214