Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies (Q35912029)

11 August 2017

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies (English)

1 reference

11 August 2017

1

Benedikt Frieg

1 reference

11 August 2017

3

Nadine Homeyer

1 reference

11 August 2017

5

Dieter Häussinger

1 reference

11 August 2017

Boris Görg

2

1 reference

PMCID

4737493

11 August 2017

Verena Keitel

series ordinal

4

1 reference

PMCID

4737493

11 August 2017

Holger Gohlke

series ordinal

6

1 reference

11 August 2017

2 February 2016

1 reference

PLOS Computational Biology

11 August 2017

1 reference

11 August 2017

12

1 reference

11 August 2017

e1004693

1 reference

11 August 2017

2

1 reference

Creative Commons Attribution 4.0 International

11 August 2017

start time

2 February 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Glutamine supplementation in a child with inherited GS deficiency improves the clinical status and partially corrects the peripheral and central amino acid imbalance

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Roles of glutamine synthetase inhibition in epilepsy

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Inhibitors of glutamine synthetase and their potential application in medicine

27 July 2018

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Inborn error of amino acid synthesis: human glutamine synthetase deficiency

27 July 2018

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AMBER force-field parameters for phosphorylated amino acids in different protonation states: phosphoserine, phosphothreonine, phosphotyrosine, and phosphohistidine

27 July 2018

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The Amber biomolecular simulation programs

27 July 2018

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Approaches to the description and prediction of the binding affinity of small-molecule ligands to macromolecular receptors

27 July 2018

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Different types of interactions involving cysteine sulfhydryl group in proteins.

27 July 2018

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Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy

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Kinetic, ESR, and trapping evidence for in vivo binding of Mn(II) to glutamine synthetase in brain cells.

27 July 2018

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Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes

27 July 2018

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Glutamine synthetase of the human brain: purification and characterization.

27 July 2018

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27 July 2018

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Hydrogen bonds involving sulfur atoms in proteins.

27 July 2018

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Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker

27 July 2018

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The Protein Data Bank. A computer-based archival file for macromolecular structures

27 July 2018

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Glutamine Synthetase: Glial Localization in Brain

27 July 2018

1 reference

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Hyperammonemia in gene-targeted mice lacking functional hepatic glutamine synthetase

27 July 2018

1 reference

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Convergence and reproducibility in molecular dynamics simulations of the DNA duplex d(GCACGAACGAACGAACGC)

24 September 2018

1 reference

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Including explicit water molecules as part of the protein structure in MM/PBSA calculations.

24 September 2018

1 reference

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Molecular dynamics simulations and structure-guided mutagenesis provide insight into the architecture of the catalytic core of the ectoine hydroxylase

24 September 2018

1 reference

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Determinants of the species selectivity of oxazolidinone antibiotics targeting the large ribosomal subunit

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Roles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related Cavities

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Protein rigidity and thermophilic adaptation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Probability distributions of hydration water molecules around polar protein atoms obtained by a database analysis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Geometric characteristics of hydrogen bonds involving sulfur atoms in proteins

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Glutamine synthetase becomes nitrated and its activity is reduced during repetitive seizure activity in the pentylentetrazole model of epilepsy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Water at biomolecular binding interfaces

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Ligand affinities predicted with the MM/PBSA method: dependence on the simulation method and the force field.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Comparison of multiple Amber force fields and development of improved protein backbone parameters

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Congenital glutamine deficiency with glutamine synthetase mutations

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Converging free energy estimates: MM-PB(GB)SA studies on the protein-protein complex Ras-Raf.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Development of polyphosphate parameters for use with the AMBER force field.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Benzodiazepine-induced protein tyrosine nitration in rat astrocytes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Glutamate-glutamine cycling in the epileptic human hippocampus

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Hepatic encephalopathy in chronic liver disease: a clinical manifestation of astrocyte swelling and low-grade cerebral edema?

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Structure-function relationships of glutamine synthetases

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease?

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

24 September 2018

Ion-pairs in proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Phosphorylation of methionine sulfoximine by glutamine synthetase

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Effects of specific divalent cations on some physical and chemical properties of glutamine synthetase from Escherichia coli. Taut and relaxed enzyme forms.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4737493

Comparison of simple potential functions for simulating liquid water

24 September 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1004693

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1004693

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1004693

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1004693

van der Waals Volumes and Radii

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1004693

Generic rigidity percolation: The pebble game

21 January 2018

1 reference

12 December 2020

Short hydrogen bonds in proteins

1 reference

12 December 2020

Natural course of glutamine synthetase deficiency in a 3 year old patient

1 reference

12 December 2020

Free Energy Calculations by the Molecular Mechanics Poisson-Boltzmann Surface Area Method

1 reference

12 December 2020

Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle

1 reference

12 December 2020

Variation of the conformational states of Escherichia coli glutamine synthetase by interaction with different divalent cations

1 reference

12 December 2020

Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver

1 reference

12 December 2020

Hydration in drug design. 1. Multiple hydrogen-bonding features of water molecules in mediating protein-ligand interactions

1 reference

12 December 2020

Hepatic glutamine transport and metabolism

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.1004693

Identifiers

DOI

1 reference

journals/ploscb/FriegGHKHG16

11 August 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

11 August 2017

1 reference

PMCID

4737493