Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. (Q35920105)

11 August 2017

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM. (English)

1 reference

11 August 2017

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1

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12 June 2020

Gabriela Pregernig

4

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12 June 2020

Alex K. Shalek

11

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12 June 2020

Ernest Fraenkel

12

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12 June 2020

8

Samuel W Kazer

1 reference

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12 June 2020

author name string

Gigi C G Choi

2

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12 June 2020

Cheryl H Cui

3

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12 June 2020

Pamela Milani

5

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12 June 2020

Miriam Adam

6

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12 June 2020

Samuel D Perli

7

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12 June 2020

Aleth Gaillard

9

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12 June 2020

Mario Hermann

10

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12 June 2020

Timothy K Lu

13

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12 June 2020

language of work or name

English

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publication date

10 February 2016

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

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12 June 2020

volume

113

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12 June 2020

issue

9

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12 June 2020

page(s)

2544-2549

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26864203%20AND%20SRC:MED&resulttype=core&format=json

Massively parallel high-order combinatorial genetics in human cells

12 June 2020

cites work

1 reference

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Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

27 July 2018

1 reference

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A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

27 July 2018

1 reference

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RNA-guided human genome engineering via Cas9

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Multiplex genome engineering using CRISPR/Cas systems

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Combinatorial drug therapy for cancer in the post-genomic era.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Cancer epigenetics: from mechanism to therapy

27 July 2018

1 reference

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Epigenetic protein families: a new frontier for drug discovery

27 July 2018

1 reference

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A programmable microfluidic cell array for combinatorial drug screening

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

False negative rates in Drosophila cell-based RNAi screens: a case study

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

The genetic landscape of a cell

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

RPN2 gene confers docetaxel resistance in breast cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Combinatorial patterns of histone acetylations and methylations in the human genome

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Epigenetic therapy of cancer: past, present and future

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Systematic discovery of multicomponent therapeutics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

High-throughput functional genomics using CRISPR-Cas9.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Unravelling the genomic targets of small molecules using high-throughput sequencing

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

RNAi screening comes of age: improved techniques and complementary approaches

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Enhanced killing of antibiotic-resistant bacteria enabled by massively parallel combinatorial genetics

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Targeted genomic rearrangements using CRISPR/Cas technology

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome-scale CRISPR-Cas9 knockout screening in human cells

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genetic screens in human cells using the CRISPR-Cas9 system

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Genome engineering using the CRISPR-Cas9 system

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

DGIdb: mining the druggable genome

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

The epigenomics of cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4780610

24 September 2018

Identifiers

DOI

10.1073/PNAS.1517883113

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26864203%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26864203%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

26864203

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26864203%20AND%20SRC:MED&resulttype=core&format=json