A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS (Q35925858)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26088135%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS (English)

1 reference

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17 February 2020

1 reference

7

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17 February 2020

author name string

Wadad AlSalmi

1

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17 February 2020

Marthandan Mahalingam

2

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17 February 2020

Neeti Ananthaswamy

3

1 reference

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17 February 2020

Christopher Hamlin

4

1 reference

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17 February 2020

Dalia Flores

5

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17 February 2020

Guofen Gao

6

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17 February 2020

language of work or name

English

0 references

publication date

18 June 2015

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Journal of Biological Chemistry

17 February 2020

published in

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17 February 2020

volume

290

1 reference

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17 February 2020

issue

32

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17 February 2020

page(s)

19780-19795

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Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

17 February 2020

cites work

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Insights into the trimeric HIV-1 envelope glycoprotein structure

2 October 2017

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A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene

2 October 2017

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Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like properties

2 October 2017

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Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

2 October 2017

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Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy

2 October 2017

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CD4-induced activation in a soluble HIV-1 Env trimer

2 October 2017

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Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.

2 October 2017

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Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

2 October 2017

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Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

2 October 2017

1 reference

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Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers

2 October 2017

1 reference

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Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer

2 October 2017

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Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

2 October 2017

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Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

2 October 2017

1 reference

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

2 October 2017

1 reference

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Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy

2 October 2017

1 reference

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Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Robust neutralizing antibodies elicited by HIV-1 JRFL envelope glycoprotein trimers in nonhuman primates

2 October 2017

1 reference

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Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein

2 October 2017

1 reference

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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

2 October 2017

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A brief history of the global effort to develop a preventive HIV vaccine

2 October 2017

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

2 October 2017

1 reference

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

2 October 2017

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In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

2 October 2017

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Identification of an HIV-1 clade A envelope that exhibits broad antigenicity and neutralization sensitivity and elicits antibodies targeting three distinct epitopes

2 October 2017

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Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.

2 October 2017

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Designing a soluble near full-length HIV-1 gp41 trimer

2 October 2017

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Role of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.

2 October 2017

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Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

2 October 2017

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HIV-1 envelope trimer elicits more potent neutralizing antibody responses than monomeric gp120.

2 October 2017

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Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers

2 October 2017

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2 October 2017

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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

2 October 2017

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Broad neutralization coverage of HIV by multiple highly potent antibodies

2 October 2017

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HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

2 October 2017

1 reference

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Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures

2 October 2017

1 reference

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HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV

2 October 2017

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Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

2 October 2017

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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

2 October 2017

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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

2 October 2017

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Molecular architecture of native HIV-1 gp120 trimers

2 October 2017

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HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

2 October 2017

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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane

2 October 2017

1 reference

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Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1.

2 October 2017

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Biology of CCR5 and its role in HIV infection and treatment

2 October 2017

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2 October 2017

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Assembly of human immunodeficiency virus (HIV) antigens on bacteriophage T4: a novel in vitro approach to construct multicomponent HIV vaccines

2 October 2017

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Selective recognition of oligomeric HIV-1 primary isolate envelope glycoproteins by potently neutralizing ligands requires efficient precursor cleavage.

2 October 2017

1 reference

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Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.

2 October 2017

1 reference

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2 October 2017

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Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants

2 October 2017

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Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.

2 October 2017

1 reference

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The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

2 October 2017

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Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin

2 October 2017

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Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteins

2 October 2017

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Vaccines for the prevention of HIV-1 disease

2 October 2017

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A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structure

2 October 2017

1 reference

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Characterization of primary isolate-like variants of simian-human immunodeficiency virus

2 October 2017

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Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo

2 October 2017

1 reference

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Protection of Macaques against pathogenic simian/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies.

2 October 2017

1 reference

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The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

2 October 2017

1 reference

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Capture of an early fusion-active conformation of HIV-1 gp41

2 October 2017

1 reference

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CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

2 October 2017

1 reference

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

2 October 2017

1 reference

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

2 October 2017

1 reference

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Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.

2 October 2017

1 reference

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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

2 October 2017

1 reference

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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

2 October 2017

1 reference

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A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

2 October 2017

1 reference

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Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry

2 October 2017

1 reference

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Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

The construction and use of a human-mouse myeloma analogue suitable for the routine production of hybridomas secreting human monoclonal antibodies

11 July 2018

1 reference

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An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4528139

Loss of serum antibodies to a conformational epitope of HIV-1/gp120 identified by a human monoclonal antibody is associated with disease progression

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26088135

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interactions of human antibodies, epitope exposure, antibody binding and neutralization of primary isolate HIV-1 virions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26088135

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M115.656611

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26088135%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26088135%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference