Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts (Q35956457)

11 August 2017

Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts (English)

1 reference

11 August 2017

Shruti Goel

1

1 reference

11 August 2017

Emily N Chin

2

1 reference

11 August 2017

Saja A Fakhraldeen

3

1 reference

11 August 2017

Scott M Berry

4

1 reference

11 August 2017

David J Beebe

5

1 reference

11 August 2017

Caroline M Alexander

6

1 reference

11 August 2017

language of work or name

English

0 references

publication date

20 March 2012

1 reference

Journal of Biological Chemistry

11 August 2017

1 reference

11 August 2017

287

1 reference

11 August 2017

20

1 reference

11 August 2017

16454-16466

1 reference

describes a project that uses

11 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3351289/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

2 October 2017

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2 October 2017

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2 October 2017

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Differentiation generates paracrine cell pairs that maintain basaloid mouse mammary tumors: proof of concept

2 October 2017

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One-step purification of nucleic acid for gene expression analysis via Immiscible Filtration Assisted by Surface Tension (IFAST)

2 October 2017

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SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease

2 October 2017

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Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies

2 October 2017

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

2 October 2017

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Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture

2 October 2017

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2 October 2017

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LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

2 October 2017

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Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis

2 October 2017

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Wnt4 is not sufficient to induce lobuloalveolar mammary development

2 October 2017

1 reference

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Towards an integrated view of Wnt signaling in development

2 October 2017

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The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage

2 October 2017

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2 October 2017

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The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

2 October 2017

1 reference

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WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth

2 October 2017

1 reference

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Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells

2 October 2017

1 reference

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

2 October 2017

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The internally truncated LRP5 receptor presents a therapeutic target in breast cancer

2 October 2017

1 reference

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Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector

2 October 2017

1 reference

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The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo

2 October 2017

1 reference

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Common integration sites for MMTV in viral induced mouse mammary tumors

2 October 2017

1 reference

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Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer

2 October 2017

1 reference

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Non-conventional Frizzled ligands and Wnt receptors.

2 October 2017

1 reference

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Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the Wnt co-receptor LRP6.

2 October 2017

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Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

2 October 2017

1 reference

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Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.

2 October 2017

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Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation

2 October 2017

1 reference

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Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor

2 October 2017

1 reference

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

2 October 2017

1 reference

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Diversity of LEF/TCF action in development and disease

2 October 2017

1 reference

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Wnt/beta-catenin signaling in development and disease

2 October 2017

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The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

2 October 2017

1 reference

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Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Generation of a functional mammary gland from a single stem cell

2 October 2017

1 reference

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Purification and unique properties of mammary epithelial stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

The Wnt signaling pathway in development and disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Wnt proteins in mammary development and cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

A mechanism for Wnt coreceptor activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Wise, a context-dependent activator and inhibitor of Wnt signalling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Role of Wnt10b and C/EBPalpha in spontaneous adipogenesis of 243 cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

An LDL-receptor-related protein mediates Wnt signalling in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Transformation by Wnt family proteins correlates with regulation of beta-catenin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Differential transformation of mammary epithelial cells by Wnt genes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

Inexpensive low-oxygen incubators.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3351289

24 September 2018

Identifiers

DOI

10.1074/JBC.M112.362137

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22433869

1 reference