The role of the unfolded protein response in tumour development: friend or foe? (Q35968425)

11 August 2017

1 reference

title

The role of the unfolded protein response in tumour development: friend or foe? (English)

1 reference

11 August 2017

Yanjun Ma

1

1 reference

11 August 2017

Linda M Hendershot

series ordinal

2

1 reference

11 August 2017

language of work or name

English

0 references

publication date

1 December 2004

1 reference

11 August 2017

Nature Reviews Cancer

1 reference

11 August 2017

4

1 reference

11 August 2017

12

1 reference

11 August 2017

966-977

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc1505

11 August 2017

0 references

cites work

Mammalian stress response: induction of the glucose-regulated protein family

1 reference

Setting the standards: quality control in the secretory pathway

31 March 2020

1 reference

ER chaperone functions during normal and stress conditions

31 March 2020

1 reference

The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct

31 March 2020

1 reference

The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins

31 March 2020

1 reference

A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

31 March 2020

1 reference

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

31 March 2020

1 reference

Dissociation of Kar2p/BiP from an ER sensory molecule, Ire1p, triggers the unfolded protein response in yeast

31 March 2020

1 reference

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response

31 March 2020

1 reference

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

31 March 2020

1 reference

The unfolded protein response and Alzheimer's disease

31 March 2020

1 reference

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

31 March 2020

1 reference

Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin

31 March 2020

1 reference

GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis

31 March 2020

1 reference

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

31 March 2020

1 reference

The glucose-regulated proteins: stress induction and clinical applications

31 March 2020

1 reference

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

31 March 2020

1 reference

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

31 March 2020

1 reference

Activation of an unfolded protein response during differentiation of antibody-secreting B cells.

31 March 2020

1 reference

Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions

31 March 2020

1 reference

Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

31 March 2020

1 reference

Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans

31 March 2020

1 reference

De-regulation of GRP stress protein expression in human breast cancer cell lines.

31 March 2020

1 reference

Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells

31 March 2020

1 reference

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

31 March 2020

1 reference

Effect on tumor cells of blocking survival response to glucose deprivation

31 March 2020

1 reference

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

31 March 2020

1 reference

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

31 March 2020

1 reference

The development of proteasome inhibitors as anticancer drugs

31 March 2020

1 reference

Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging

31 March 2020

1 reference

The vascular network of tumours — what is it not for?

31 March 2020

1 reference

Regulated translation initiation controls stress-induced gene expression in mammalian cells

31 March 2020

1 reference

Herp is dually regulated by both the endoplasmic reticulum stress-specific branch of the unfolded protein response and a branch that is shared with other cellular stress pathways

31 March 2020

1 reference

HIF-1 and hypoxic response: the plot thickens.

31 March 2020

1 reference

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

31 March 2020

1 reference

Regulation of angiogenesis by hypoxia: role of the HIF system

31 March 2020

1 reference

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

31 March 2020

1 reference

Activating transcription factor 4 is translationally regulated by hypoxic stress

31 March 2020

1 reference

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

31 March 2020

1 reference

Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

31 March 2020

1 reference

The biology of vascular endothelial growth factor

31 March 2020

1 reference

Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.

31 March 2020

1 reference

Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150

31 March 2020

1 reference

Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport.

31 March 2020

1 reference

Coordinated activation of Hsp70 chaperones

31 March 2020

1 reference

Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies

31 March 2020

1 reference

Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy.

31 March 2020

1 reference

Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.

31 March 2020

1 reference

Green fluorescent protein tagging of extracellular signal-regulated kinase and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth

31 March 2020

1 reference

Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target [...]

31 March 2020

1 reference

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

31 March 2020

1 reference

PERK mediates cell-cycle exit during the mammalian unfolded protein response

31 March 2020

1 reference

Regulation of apoptosis by endoplasmic reticulum pathways.

31 March 2020

1 reference

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

31 March 2020

1 reference

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

31 March 2020

1 reference

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

31 March 2020

1 reference

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

31 March 2020

1 reference

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

31 March 2020

1 reference

Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis

31 March 2020

1 reference

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

31 March 2020

1 reference

Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts

31 March 2020

1 reference

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

1 reference

Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis

31 March 2020

1 reference

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

31 March 2020

1 reference

Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation

31 March 2020

1 reference

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress

31 March 2020

1 reference

Somatic mutations of CASP3 gene in human cancers.

31 March 2020

1 reference

Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

31 March 2020

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

DNA topoisomerases: essential enzymes and lethal targets

31 March 2020

1 reference

Antitopoisomerase drug action and resistance

31 March 2020

1 reference

Tumor cell death induced by topoisomerase-targeting drugs.

31 March 2020

1 reference

Depletion of topoisomerase II in isolated nuclei during a glucose-regulated stress response

31 March 2020

1 reference

Down-regulation of topoisomerase II alpha is caused by up-regulation of GRP78.

31 March 2020

1 reference

Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78

31 March 2020

1 reference

Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation

31 March 2020

1 reference

The making of the mitotic chromosome: modern insights into classical questions

31 March 2020

1 reference

Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.

31 March 2020

1 reference

Interactions between mammalian cell DNA and inorganic platinum compounds. I. DNA interstrand cross-linking and cytotoxic properties of platinum(II) compounds

31 March 2020

1 reference

Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress

31 March 2020

1 reference

Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling

31 March 2020

1 reference

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

31 March 2020

1 reference

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

31 March 2020

1 reference

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

31 March 2020

1 reference

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

31 March 2020

1 reference

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

31 March 2020

1 reference

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

31 March 2020

1 reference

Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response

31 March 2020

1 reference

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

31 March 2020

1 reference

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

31 March 2020

1 reference

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

31 March 2020

1 reference

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

31 March 2020

1 reference

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

31 March 2020

1 reference

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

31 March 2020

1 reference

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

31 March 2020

1 reference

JAB1 participates in unfolded protein responses by association and dissociation with IRE1

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1505

1 reference

Dimensions Publication ID

11 August 2017

0 references

1 reference