Small molecules, big targets: drug discovery faces the protein-protein interaction challenge (Q35981250)

11 August 2017

Small molecules, big targets: drug discovery faces the protein-protein interaction challenge (English)

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protein-protein interaction

11 August 2017

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4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Duncan E Scott

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Andrew R Bayly

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Chris Abell

series ordinal

3

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2 June 2020

publication date

11 April 2016

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Nature Reviews Drug Discovery

11 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27050677%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

533-550

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https://scigraph.springernature.com/pub.10.1038/nrd.2016.29

2 June 2020

exact match

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Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

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Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis

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Integrins as therapeutic targets: lessons and opportunities

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Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide

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A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex

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High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction

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Binding of small molecules to an adaptive protein-protein interface

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Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

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Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions

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Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

21 January 2018

1 reference

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Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Structure-function relationships for the interleukin 2 receptor: location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor

21 January 2018

1 reference

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Hot-spot mimicry of a cytokine receptor by a small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

The Use of Chlorobenzene as a Probe Molecule in Molecular Dynamics Simulations

21 January 2018

1 reference

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Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy

21 January 2018

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Dissecting protein-protein recognition sites

21 January 2018

1 reference

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Conservation of polar residues as hot spots at protein interfaces

31 March 2020

1 reference

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The structure of interfaces between subunits of dimeric and tetrameric proteins

31 March 2020

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Morphology of protein-protein interfaces.

31 March 2020

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The structure of interleukin-2 complexed with its alpha receptor

31 March 2020

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Protein–Protein Interaction Inhibitors: Case Studies on Small Molecules and Natural Compounds

31 March 2020

1 reference

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Fragment-based deconstruction of Bcl-xL inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Stapled peptides: Magic bullets in nature's arsenal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Atomic structure of a short alpha-helix stabilized by a main chain hydrogen-bond surrogate

31 March 2020

1 reference

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Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Targeting the BH3 domain mediated protein-protein interaction of Bcl-xL through virtual screening

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Structure-based design of potent, conformationally constrained Smac mimetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2016.29

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search

31 March 2020

1 reference

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Protein-protein interaction detection: methods and analysis

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27050677

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27050677