Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes (Q36006967)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22451661%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes (English)

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27 January 2020

2

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27 January 2020

author name string

Nidhi Bhutani

1

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27 January 2020

Raphael Hourez

3

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27 January 2020

Prasanna Venkatraman

4

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27 January 2020

Alfred L Goldberg

5

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27 January 2020

language of work or name

English

0 references

publication date

27 March 2012

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Journal of Biological Chemistry

27 January 2020

published in

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27 January 2020

volume

287

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27 January 2020

issue

21

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27 January 2020

page(s)

17471-17482

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Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin

27 January 2020

cites work

1 reference

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Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy

2 October 2017

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Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus

2 October 2017

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A gene network regulating lysosomal biogenesis and function

2 October 2017

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Small molecule regulators of autophagy identified by an image-based high-throughput screen

2 October 2017

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Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

2 October 2017

1 reference

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Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation

2 October 2017

1 reference

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Emerging roles of cysteine cathepsins in disease and their potential as drug targets.

2 October 2017

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

2 October 2017

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Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

2 October 2017

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The roles of intracellular protein-degradation pathways in neurodegeneration

2 October 2017

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Dynein mutations impair autophagic clearance of aggregate-prone proteins

2 October 2017

1 reference

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Inefficient degradation of truncated polyglutamine proteins by the proteasome

2 October 2017

1 reference

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

2 October 2017

1 reference

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Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases

2 October 2017

1 reference

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2 October 2017

1 reference

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Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

2 October 2017

1 reference

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Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Lysosomal cysteine proteases: facts and opportunities

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Proteasome inhibitors: from research tools to drug candidates

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Impairment of the ubiquitin-proteasome system by protein aggregation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

2 October 2017

1 reference

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Solubilization and disaggregation of polyglutamine peptides

2 October 2017

1 reference

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Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling

2 October 2017

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Glutamine repeats and neurodegeneration

2 October 2017

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Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

2 October 2017

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Aggresomes: a cellular response to misfolded proteins

2 October 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

2 October 2017

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Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

2 October 2017

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Cystine transport in purified rat liver lysosomes

2 October 2017

1 reference

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Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

11 July 2018

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Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Intra- and intermolecular beta-pleated sheet formation in glutamine-repeat inserted myoglobin as a model for polyglutamine diseases

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3366842

23 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.352781

Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22451661

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.352781

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22451661%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22451661%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference