Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice (Q36025303)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932569%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice (English)

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8 January 2020

3

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8 January 2020

11

Craig M Coopersmith

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8 January 2020

author name string

Daniel B Graham

1

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8 January 2020

Charles M Robertson

2

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8 January 2020

Francesca Mascarenhas

4

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8 January 2020

M Julia Diacovo

5

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8 January 2020

Vivianne Montgrain

6

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8 January 2020

Siu Kit Lam

7

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8 January 2020

Viviana Cremasco

8

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8 January 2020

W Michael Dunne

9

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8 January 2020

Roberta Faccio

10

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8 January 2020

Wojciech Swat

12

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8 January 2020

language of work or name

English

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publication date

1 November 2007

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Journal of Clinical Investigation

8 January 2020

published in

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8 January 2020

volume

117

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8 January 2020

page(s)

3445-3452

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8 January 2020

issue

11

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The expanding role for ITAM-based signaling pathways in immune cells

8 January 2020

cites work

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Vav proteins control MyD88-dependent oxidative burst

2 October 2017

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

2 October 2017

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The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity

2 October 2017

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Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.

2 October 2017

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2 October 2017

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Molecular composition and regulation of the Nox family NAD(P)H oxidases

2 October 2017

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2 October 2017

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Guidelines for the Management of Adults with Hospital-acquired, Ventilator-associated, and Healthcare-associated Pneumonia

2 October 2017

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PRAM-1 is required for optimal integrin-dependent neutrophil function

2 October 2017

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Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

2 October 2017

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2 October 2017

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Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

2 October 2017

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NADPH oxidases: not just for leukocytes anymore!

2 October 2017

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

2 October 2017

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2 October 2017

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The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

2 October 2017

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Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

2 October 2017

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Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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11 July 2018

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Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid

23 September 2018

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Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles

23 September 2018

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SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils

23 September 2018

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The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

23 September 2018

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Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading

23 September 2018

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Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions

23 September 2018

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Syk is required for integrin signaling in neutrophils

23 September 2018

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Long-term follow-up and outcome of 39 patients with chronic granulomatous disease.

23 September 2018

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Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck

23 September 2018

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Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)

21 October 2018

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12 December 2020

Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways

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12 December 2020

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

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12 December 2020

Respiratory burst in adherent human neutrophils: triggering by colony-stimulating factors CSF-GM and CSF-G

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12 December 2020

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

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12 December 2020

Antigen receptor signaling: the Tuscan chronicles

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12 December 2020

Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma

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12 December 2020

Identifiers

DOI

10.1172/JCI32729

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932569%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932569%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference